A0A1X0NZ27 · A0A1X0NZ27_9TRYP
- ProteinDihydroorotate dehydrogenase (fumarate)
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids313 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.
Catalytic activity
- (S)-dihydroorotate + fumarate = orotate + succinate
Cofactor
Pathway
Pyrimidine metabolism; UMP biosynthesis via de novo pathway.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | dihydroorotate dehydrogenase (fumarate) activity | |
Biological Process | 'de novo' pyrimidine nucleobase biosynthetic process | |
Biological Process | 'de novo' UMP biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDihydroorotate dehydrogenase (fumarate)
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma
Accessions
- Primary accessionA0A1X0NZ27
Proteomes
Organism-specific databases
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-294 | Dihydroorotate dehydrogenase catalytic | ||||
Sequence: LKVNILGHEFANPLMNAAGVLCSTIDDLQCMTASSSGSLVSKSCTTAHRDGNPEPRYCGLPLGSINSMGLPNLGFDVYLKYANEQHDYGRKPLFLSMSGLSAEENAAMCKRLAPVAKEKGVVLELNLSCPNVPGKPQVAYDFDTMRVYLKEVSEAYGLPFGVKMPPYFDIAHFDMAAAVLNEFPLVKFVTCVNSIGNGLVIDPATETVVIKPKQGFGGVGGKYILPTALANVNAFYRRCPDKLVFGCGGVYTGEDVFLHILAGASMVQVGTALHEEGPAIFDRLATELQEIM |
Sequence similarities
Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length313
- Mass (Da)33,875
- Last updated2017-07-05 v1
- Checksum1BF2299553CB89A0
Keywords
- Technical term