A0A1X0NYV7 · A0A1X0NYV7_9TRYP

  • Protein
    Katanin p60 ATPase-containing subunit A1
  • Gene
    KATNA1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • n ATP + n H2O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
    EC:5.6.1.1 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site.

156450100150200250300350400450500550
TypeIDPosition(s)Description
Binding site320-327ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmicrotubule
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionisomerase activity
Molecular Functionmicrotubule binding
Molecular Functionmicrotubule severing ATPase activity
Biological Processmicrotubule severing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Katanin p60 ATPase-containing subunit A1
  • EC number
  • Short names
    Katanin p60 subunit A1
  • Alternative names
    • p60 katanin

Gene names

    • Name
      KATNA1
    • ORF names
      TM35_000113150

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Edinburgh
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma

Accessions

  • Primary accession
    A0A1X0NYV7

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias96-135Polar residues
Region96-249Disordered
Compositional bias204-244Polar residues
Domain312-449AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    564
  • Mass (Da)
    61,971
  • Last updated
    2017-07-05 v1
  • Checksum
    C2592586B355B470
MCDLFTIVSSSEKSLRLARRYALESNYDVAVAFYTGIDKDLTNCMQCRSDGSQSGKNGSGDLSDVALLREKVAEECVLVRAIQAELKALINPSSAVQLDRPPQESNAETTTAPSRAATTRPLRRTTVTNTNGANPVAAARPAVMSVPPPMSTAARNEALYGDPDRFGPPRLKTPLRNSSPLARRRPVGGSLRAASPPRSTRPKAALPLQTQSQQTLRAGRTPAASSSAAVSSTNNNTTSRPRRQGARATLPRFVARPGEEELVSLIEADMHVGPLAVSWDDVAGLSAAKGLLEEAVVYPVLMPDYYTGIRRPWKGVLLYGPPGTGKTMLAKAVASECNTTFFNISPATLTSKWRGDSEKLIRVLFEMARYYAPSTIFIDEIDSLCGQRGDGGEHEASRRAKGTLLAQMDGVGVDPGKIVMVLGATNHPWSIDEAMRRRLEKRIYIPLPDFNDRLELFRINTKTLKLSPDVDFTKLSKILEGRYYSCADITNLVRDAAMMTMRRFMEETDKTELKRRAAEIGKLVAEQPTTMKDFLDAVKNVPSSINVDQITRFEKWKKEFETNL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias96-135Polar residues
Compositional bias204-244Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NBCO01000011
EMBL· GenBank· DDBJ
ORC89781.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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