A0A1X0NU16 · A0A1X0NU16_9TRYP

  • Protein
    Leishmanolysin-like peptidase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.
    EC:3.4.24.36 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

159950100150200250300350400450500550
TypeIDPosition(s)Description
Binding site229Zn2+ (UniProtKB | ChEBI); catalytic
Active site230
Binding site233Zn2+ (UniProtKB | ChEBI); catalytic
Binding site297Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processcell adhesion
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Leishmanolysin-like peptidase
  • EC number

Gene names

    • ORF names
      TM35_000192170

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Edinburgh
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma

Accessions

  • Primary accession
    A0A1X0NU16

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane574-593Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_502397014825-599Leishmanolysin-like peptidase

Keywords

Family & Domains

Sequence similarities

Belongs to the peptidase M8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    599
  • Mass (Da)
    66,916
  • Last updated
    2017-07-05 v1
  • Checksum
    739D112B5F4926FC
MRQLLYVTVLLLVLLPLYCTNGLAATGGRSCGFDAVRRRRGNTPVAVVRELPVKGQGPWQAYTAATYSPWAPIRIFVSTIDLEDDSRYCPAAGRYRPIYVDKRYVHCQPKDVLRDEQRNALINHIIPGAMKLHQERLLVKPLKGTFKVPVFGEHDTCSQFSVPPEHYNPGFSGYDTVMYAAAGPQHMEGTVAWAIKCATLPNGRPVTGILYFTPQYITNTSQMVRAAAHEMAHVLGFHGEVFIKQSDMYARRLRGLEKVPFLKCPKLVEKAKKHYNCSSLDGVEMENDGDDFTALSHWDVRSAKDELMAAFSGIGYYTALTMAAFECTRYYKANWGMEETMSWGKDAGCSLHTDKCIKENVTEFPDLFCTALSETPVCTSDRRALGICTLGVYNADLPEEYRYFTNPRVGGVYEYMTDYCPFISPIPYGDCKASISYGYLGSRIGPSSWCLKGESLMLNGTIVGDVCAEVQCDNKSVQVRYYGDDKWYPCPEGKVLKPNNTFTSGSIVCPKYREVCTIAADGSSRIVKKIIPEARHSSDTESSMGPTVTLESVDYRTEGEMSDKKEVAGFFERFLAALSAFFLFLLALFSNILKPCLHL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NBCO01000019
EMBL· GenBank· DDBJ
ORC87973.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp