A0A1X0NTC6 · A0A1X0NTC6_9TRYP

  • Protein
    RNA cytidine acetyltransferase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N4-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site318-327ATP (UniProtKB | ChEBI)
Binding site499ATP (UniProtKB | ChEBI)
Binding site658-660acetyl-CoA (UniProtKB | ChEBI)
Binding site665-671acetyl-CoA (UniProtKB | ChEBI)
Binding site761acetyl-CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Component90S preribosome
Cellular Componentnucleolus
Molecular FunctionATP binding
Molecular FunctionrRNA cytidine N-acetyltransferase activity
Molecular FunctiontRNA binding
Molecular FunctiontRNA N-acetyltransferase activity
Biological ProcessrRNA acetylation involved in maturation of SSU-rRNA
Biological ProcesstRNA acetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    RNA cytidine acetyltransferase
  • EC number
  • Alternative names
    • 18S rRNA cytosine acetyltransferase

Gene names

    • ORF names
      TM35_000201320

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Edinburgh
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma

Accessions

  • Primary accession
    A0A1X0NTC6

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain, compositional bias.

TypeIDPosition(s)Description
Region1-24Disordered
Domain30-224tRNA(Met) cytidine acetyltransferase TmcA N-terminal
Domain312-517Helicase
Domain558-788N-acetyltransferase
Region691-721Disordered
Domain797-997Possible tRNA binding
Region971-1001Disordered
Region1034-1061Disordered
Compositional bias1036-1051Polar residues

Sequence similarities

Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,061
  • Mass (Da)
    117,670
  • Last updated
    2017-07-05 v1
  • Checksum
    0124E3A7B9DB300C
MSSSASVVSTAHSARGGSGGGVTIKRKVDDRIRNLIENAVHKKHRALILLVGDRGKDQIVNLHQMVSHANHNAKVNMLWCMKKDPDFGSTSKKQQEKRARLEVKGGMSTETTKEAFQTFLSQTQIRFCQYKETHKVLGQTFGMAVLQDFEAITPNTLARTIETVKGGGVVVIMFRAMRSLKQLYTIAMDVHSRYRTEALRDVVPRFNERFLLSLVDCDTALCVDDDLNVLPITAKMRAVESMRTSNKSNYDADLALQGRQKHEADLAALKERLRASNEVGPLVSLCQTLDQGKTVLSLMQTVVEKSLNTTCVVTAGRGRGKSAALGLAAAGALAQGYSNIFCTAPSPENLQTFFEFVVRGLQEQGYKERTDFEAMQSTNVEFSKCIVRINLFREHRQTVQYISPHDADKFAQAELAIIDEAAALPLPLVKQMLGPYLVFLSSTVSGYEGTGRSLSMKLIADMRKQSGSIVGGSSSTSTAVSTSDDRRFLREITMTDPIRYGPNDPVESWLHKLLCLDATVRPLTVKSCPHPNKCELYYVNRDALFSYHPLAEQLLQTVVAMLVAAHYKNQPNDLQLMSDAPGHHLFLLCSSTVETNGELPDVFCVIHACEEGQVTSESIKSNLSRGVRPSGDLIPYTLSQYYLEEGFAKLAGLRIVRIATNPELQRAGYGSRALELLQQYYTGSISLQPASSESLKTKEETENNNNDNDDNDDTNSTSNVITPRKRIPSLLTSLVERPYEVIDYLGVSFGVTTPLFNFWKRAGYEALYLRHAANELTGEHSCVMVRPIGFDLSLLRAEFHQRFIPLLSMPFRDLPTELALSILNDLDVNDPQKLAAATDHSQSSEHIVRVGGRLQCTLRELQLIFNQNDMKRLRLNATTFVEGGLVLDLLPALAKLYFEARLHRLPDGSEGVVLTHAQAAVLLAVGLQCQTIEELSRQSAFAGVPLQQLRAFLQKAVARIVEHFTRLEKLKTPQEANGHSSVKNGEEGEEEDGEQEQTREIYDKDGHVVGLSVEKKVQRVVNVDTTLLRDAKTAAIGTSKSESGTTGIQRAFKRSKKTRRS

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1036-1051Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NBCO01000020
EMBL· GenBank· DDBJ
ORC87723.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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