A0A1X0NK29 · A0A1X0NK29_9TRYP

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.
    EC:3.4.24.36 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

1923100200300400500600700800900
Type
IDPosition(s)Description
Binding site228Zn2+ (UniProtKB | ChEBI); catalytic
Active site229
Binding site232Zn2+ (UniProtKB | ChEBI); catalytic
Binding site309Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processcell adhesion
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    leishmanolysin
  • EC number
  • Alternative names
    • Cell surface protease
    • Major surface glycoprotein
    • Protein gp63

Gene names

    • ORF names
      TM35_000381990

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Edinburgh
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma

Accessions

  • Primary accession
    A0A1X0NK29

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane903-922Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-25
ChainPRO_501334389526-923leishmanolysin

Keywords

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region575-875Disordered
Compositional bias585-602Polar residues
Compositional bias610-651Basic and acidic residues
Compositional bias652-739Polar residues
Compositional bias756-824Polar residues
Compositional bias825-840Basic and acidic residues
Compositional bias841-875Polar residues

Sequence similarities

Belongs to the peptidase M8 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    923
  • Mass (Da)
    101,654
  • Last updated
    2017-07-05 v1
  • Checksum
    83499B211C1A64F2
MEKHSMRHILWAALFLLYCSCGCLAAVVQQLPQKGESALQAYTVSAPPAPPAAPKTGVEWQPIRIAVYTKRVEDVLKFCTTGALPPEYQDEFLETDEVEDEFEELCGVKGVNKKIIAERKEILLNKVLPKAIKLHADRLNVEQVKESLKIETDSVKKPPQECGEFGIPKEHETNGIPNADFVIYARLSTNIGHGICSKDKQGRPTSAVIKFVLYDIEATRKYIRFTAHEIAHGLGFQHDLMKGLGMIVSSKTYLKPDAVPCSKKRSAGTSDYMVKFKEALEVLKNHYKCQGDEVKGLCLENDDQWTPSHWEREFAKDELMSTYIGEPTGMYYTALTLAAFHGMSFYRANFSMAEPMGWSNQSICEFLQGKKDPTQTDRPYMFCKENEKKEILQCTSDRFALGMCLTKKNLGQLPNGYQYFHGEDSETTMDDLMDGYPIIRPLNGTVCEGGDENLLPGSLLGRDSRCLNAKGLFLRDPNGHRSHTMGGVCAKVKCDNANKKVSVQLKGYDKKKELIWHECNDDNAAVKLEGSFFESGTIKCPKYEEVCTGLPKTNSLKIKYYSGKQDLEARDVVVNDDDEETGAATNTDVRAQETTTRSPFSPDAVVNEPHVPHTEQEEVKESPENKHPDKPEDTSLKRPSSDTKIEQPHQEVNKPIESQNSSPNNPRIENNHDNGLPSRSAGSSSGIGSASGIHNGGVSRGTNDDNSSALGSGASGNERNPVNGDQSVQSETSSSAPVVPVVPAKTPAAPAPADTDTNEIPQQPADSRAENKDQQNGIQTPTQAQDRQQGPNQTQNEVQFPNEVKTPSQQSTPQYKNSSTSPTTDEKDAQEEDHTSRNRRNTDAATSPNTSYPNTGDAANDQSSHTVNSDSLKVPNLTEDQIKEETLNHTNVMSALGPDSSIMFSHMAPLALLMCVVGFVMVP

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias585-602Polar residues
Compositional bias610-651Basic and acidic residues
Compositional bias652-739Polar residues
Compositional bias756-824Polar residues
Compositional bias825-840Basic and acidic residues
Compositional bias841-875Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NBCO01000038
EMBL· GenBank· DDBJ
ORC85124.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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