A0A1X0NF41 · A0A1X0NF41_9TRYP

  • Protein
    Leishmanolysin-like peptidase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

  • Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-|-Leu-Lys-Lys-.
    EC:3.4.24.36 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

161350100150200250300350400450500550600
Type
IDPosition(s)Description
Binding site211Zn2+ (UniProtKB | ChEBI); catalytic
Active site212
Binding site215Zn2+ (UniProtKB | ChEBI); catalytic
Binding site280Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmembrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processcell adhesion
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Leishmanolysin-like peptidase
  • EC number

Gene names

    • ORF names
      TM35_001251020

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Edinburgh
  • Taxonomic lineage
    Eukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Trypanosoma

Accessions

  • Primary accession
    A0A1X0NF41

Proteomes

Organism-specific databases

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-24
ChainPRO_502396633125-613Leishmanolysin-like peptidase

Keywords

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region513-604Disordered
Compositional bias538-552Basic and acidic residues
Compositional bias553-601Polar residues

Sequence similarities

Belongs to the peptidase M8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    613
  • Mass (Da)
    68,774
  • Last updated
    2017-07-05 v1
  • MD5 Checksum
    804EC7F662856D581C5A3B97FE54E4DD
MTRQMHVSLFFLLLLFLFVQLCSTSGILAEEQSTEVVQEVPKEGQGASWGYTIVTTNRTFIRINTSTEDLTEDKYCTAVGEVIKDFKEEDAQCQGHFVLSEKMKKTFLDTILPAAIKLHADRLLVDPVEGPLKVPEFEEGSVCKNFTVPPKHRKEGVENADMVLYVAARPENAFGVPCAYDDKSGRPVAGAINVQIYPLKIQRYNVRRVAHEIAHALGFDYKVFEKNNMVAKIESNDRKGRVVVNSNQTKKMTQKYYNCNELEGLELGYVDKVHTPAWSHLAWRNTNDDLMSFMYLFGAMHYSALTMSVFDDLPFYTVNWGMEESMSWGNQSGCELFKSECKAEDATKYPGRFCDINKDKNVFSCTSDRLGFGTCKQHGDDRHPENKQKCFVSESVIHPYYEKGKDHMFLLCSEIPLFNFPGSIFGNNDSLCLDTEEYSAEVSENGEMGLTGICARVSCDEGKVRVMYDGISGWQDCSENTSIEVNHPDSSNIIKIKCPKYSEVCTIFSDGSSLLPQIEPKRPPAPATTTTTTTTENNESHQEQGETHHTESGHTNNNSSSVPSQSAERTQDTTGVNVSTNENVTVPRTTEGNINKDNLTSPRVKEELKIRMG

Features

Showing features for compositional bias, non-terminal residue.

Type
IDPosition(s)Description
Compositional bias538-552Basic and acidic residues
Compositional bias553-601Polar residues
Non-terminal residue613

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NBCO01000125
EMBL· GenBank· DDBJ
ORC81207.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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