A0A1W7M575 · A0A1W7M575_SALSA
- ProteinProtein phosphatase 1A
- GenePPM1A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids384 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Catalytic activity
- O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate
Cofactor
Protein has several cofactor binding sites:
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | membrane | |
Cellular Component | nucleus | |
Molecular Function | magnesium ion binding | |
Molecular Function | manganese ion binding | |
Molecular Function | myosin phosphatase activity | |
Biological Process | negative regulation of canonical NF-kappaB signal transduction | |
Biological Process | peptidyl-threonine dephosphorylation | |
Biological Process | positive regulation of canonical NF-kappaB signal transduction | |
Biological Process | positive regulation of canonical Wnt signaling pathway |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameProtein phosphatase 1A
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Salmoninae > Salmo
Accessions
- Primary accessionA0A1W7M575
Subcellular Location
PTM/Processing
Keywords
- PTM
Interaction
Subunit
Monomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with the phosphorylated form of IKBKB/IKKB.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 23-292 | PPM-type phosphatase | ||||
Sequence: TYGLSSMQGWRVEMEDAHTAVIGLPHGLDPWAFFAVYDGHAGSQVAKYCCGHLLEHITSNPDFQSALEPEPNVESVKTGIRTGFLQIDEHMRSISEKKHGVDRSGSTAVGVMISPGHIYFINCGDSRGLLSRGGAVHFFTQDHKPSNPPEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKSPTEQLVSPEPEVYAIERSEVEDEFIVLACDGIWDVMANEELCNFVRPRLEVTDDLERVCNEVVDTCLYKGSRDNMSVVLICL |
Sequence similarities
Belongs to the PP2C family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length384
- Mass (Da)42,378
- Last updated2017-07-05 v1
- Checksum025F4FC5C7FE1B33