A0A1W7M575 · A0A1W7M575_SALSA

Function

function

Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentmembrane
Cellular Componentnucleus
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Molecular Functionmyosin phosphatase activity
Biological Processnegative regulation of canonical NF-kappaB signal transduction
Biological Processpeptidyl-threonine dephosphorylation
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of canonical Wnt signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein phosphatase 1A
  • Alternative names
    • Protein phosphatase 2C isoform alpha

Gene names

    • Name
      PPM1A

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Salmoninae > Salmo

Accessions

  • Primary accession
    A0A1W7M575

Subcellular Location

Cytoplasm, cytosol
Membrane
; Lipid-anchor
Nucleus

Keywords

PTM/Processing

Keywords

Interaction

Subunit

Monomer. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with SMAD2; the interaction dephosphorylates SMAD2 in its C-terminal SXS motif resulting in disruption of the SMAD2/SMAD4 complex, SMAD2 nuclear export and termination of the TGF-beta-mediated signaling. Interacts with the phosphorylated form of IKBKB/IKKB.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-292PPM-type phosphatase

Sequence similarities

Belongs to the PP2C family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    384
  • Mass (Da)
    42,378
  • Last updated
    2017-07-05 v1
  • Checksum
    025F4FC5C7FE1B33
MGAFLDKPKMEKYNAHGEGNRLTYGLSSMQGWRVEMEDAHTAVIGLPHGLDPWAFFAVYDGHAGSQVAKYCCGHLLEHITSNPDFQSALEPEPNVESVKTGIRTGFLQIDEHMRSISEKKHGVDRSGSTAVGVMISPGHIYFINCGDSRGLLSRGGAVHFFTQDHKPSNPPEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKSPTEQLVSPEPEVYAIERSEVEDEFIVLACDGIWDVMANEELCNFVRPRLEVTDDLERVCNEVVDTCLYKGSRDNMSVVLICLPGAPKVTAEAVKREAELDKYLESRVEEIIKKQGNEGVPDLVHVMRTLALESIPNLPPGGELASKRSVIEAVYNKLNPYRGDDTDSASTDDMW

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LT174682
EMBL· GenBank· DDBJ
CZQ42533.1
EMBL· GenBank· DDBJ
mRNA

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Disclaimer

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