A0A1W7M1X8 · A0A1W7M1X8_ONCMY
- ProteinProtein phosphatase 2C isoform beta
- GenePPM1B
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids380 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate
Cofactor
Protein has several cofactor binding sites:
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | membrane | |
Cellular Component | nucleus | |
Molecular Function | magnesium ion binding | |
Molecular Function | manganese ion binding | |
Molecular Function | myosin phosphatase activity | |
Biological Process | negative regulation of canonical NF-kappaB signal transduction | |
Biological Process | peptidyl-threonine dephosphorylation | |
Biological Process | positive regulation of canonical NF-kappaB signal transduction | |
Biological Process | positive regulation of canonical Wnt signaling pathway |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Protacanthopterygii > Salmoniformes > Salmonidae > Salmoninae > Oncorhynchus
Accessions
- Primary accessionA0A1W7M1X8
Subcellular Location
PTM/Processing
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: MGAFLDKPKTEKHTAH | ||||||
Region | 1-22 | Disordered | ||||
Sequence: MGAFLDKPKTEKHTAHGQGNGL | ||||||
Domain | 23-290 | PPM-type phosphatase | ||||
Sequence: HYGLGSMQGWRVEMEDAHTAMVGLPQGLNDWSFFAVYDGHAGSRVANYCSAHLLEHILLGGAEFTPGMGSVEGVKDGIRAGFLRIDEYMRNFSDLRHGLDRSGSTAVGVLLSPSHLYFINCGDSRAVLSREGRVGFSTQDHKPCNPREKERIQNAGGSVMIQRVNGSLAVSRALGDYDYKCVDGKGPTEQLVSPEPEVCVLERAAEGDEFVVLACDGIWDVMSNEELCEFVRSRLQVFDDLERVCNTVVDTCLHKGSRDNMSVVLVTL |
Sequence similarities
Belongs to the PP2C family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length380
- Mass (Da)41,622
- Last updated2017-07-05 v1
- ChecksumCBA2CB4CCE4CFFEE
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1-16 | Basic and acidic residues | ||||
Sequence: MGAFLDKPKTEKHTAH |