Essential maintenance is planned to begin on Tue Jan 28 2025. The website may be temporarily unavailable. Please use our fallback: https://wwwdev.ebi.ac.uk/uniprot/front-end/fallback/ during this time.

A0A1W6SBI2 · A0A1W6SBI2_9PLVG

Function

Catalytic activity

  • Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus.
    EC:3.1.26.13 (UniProtKB | ENZYME | Rhea)

GO annotations

AspectTerm
Molecular Functionendonuclease activity
Molecular FunctionRNA stem-loop binding
Molecular FunctionRNA-directed DNA polymerase activity

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Reverse transcriptase

Gene names

    • Name
      pol

Organism names

  • Taxonomic identifier
  • Strain
    • A99165_PLASMA_wk20_P23L6_o606
  • Taxonomic lineage
    Viruses > Riboviria > Pararnavirae > Artverviricota > Revtraviricetes > Ortervirales > Retroviridae > Orthoretrovirinae > Lentivirus > Primate lentivirus group

Accessions

  • Primary accession
    A0A1W6SBI2

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-191Reverse transcriptase

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    256
  • Mass (Da)
    29,737
  • Last updated
    2017-07-05 v1
  • MD5 Checksum
    6AD5BF26D3DD8ED2648C43A50D1E0965
EGKISKIGPENPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWTVQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEA

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue256

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MF029851
EMBL· GenBank· DDBJ
ARO81354.1
EMBL· GenBank· DDBJ
Other RNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help