A0A1W6JSI0 · A0A1W6JSI0_9CAUD

Function

function

Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.

Catalytic activity

  • Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.
    EC:3.2.1.17 (UniProtKB | ENZYME | Rhea)
  • Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.
    EC:3.5.1.28 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

124420406080100120140160180200220240
TypeIDPosition(s)Description
Active site20Proton donor/acceptor
Active site29Proton donor/acceptor

GO annotations

AspectTerm
Cellular Componenthost cell cytoplasm
Molecular Functionlysozyme activity
Biological Processcell wall macromolecule catabolic process
Biological Processdefense response to bacterium
Biological Processpeptidoglycan catabolic process
Biological Processviral release from host cell by cytolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endolysin
  • EC number
  • Alternative names
    • Lysis protein
    • Lysozyme
    • Muramidase

Gene names

    • ORF names
      HARAMBE_26

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Viruses > Duplodnaviria > Heunggongvirae > Uroviricota > Caudoviricetes > Salasmaviridae > Harambevirus > Harambevirus harambe

Accessions

  • Primary accession
    A0A1W6JSI0

Proteomes

Subcellular Location

Host cytoplasm
Note: The endolysin is cytoplasmic, but can reach the periplasmic space with the help of the holins which disrupt the host cell membrane.

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain168-235SH3b

Sequence similarities

Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.
Belongs to the glycosyl hydrolase 24 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    244
  • Mass (Da)
    27,636
  • Last updated
    2017-07-05 v1
  • Checksum
    7641DDFAE2F828AB
MKARHMSVSQTGVELVKHFEGCYLKAYQDVVGVWTIGYGNTQKENAYRGNVITQAKADQLLMQDLNSHMRVPKEDITVDLNQNQYDALCSFAFNLGAYIFRNNRNLLDAINYGNWNEASRIMNLFNRAGGKVYAGLVRRRKAETELMLKPMDNVSHETNGYDSSWFTPQQGTFKLDRAINLRTSPVNGDIIATLQAGDEVNYDAYGYEADGYVWIRQPRSNGYGYIATGDTSGGKRTSYWGEFQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY821088
EMBL· GenBank· DDBJ
ARM70175.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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