A0A1W6BQF7 · A0A1W6BQF7_GOBRA
- ProteinCellular tumor antigen p53
- Genep53
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids366 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | DNA-binding transcription factor activity | |
Molecular Function | metal ion binding | |
Molecular Function | transcription cis-regulatory region binding | |
Biological Process | anatomical structure morphogenesis | |
Biological Process | apoptotic process | |
Biological Process | epithelium development | |
Biological Process | protein tetramerization |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameCellular tumor antigen p53
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Gobionidae > Sarcocheilichthyinae > Gobiocypris
Accessions
- Primary accessionA0A1W6BQF7
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Cross-link | 253 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K |
Keywords
- PTM
Interaction
Subunit
Binds DNA as a homotetramer.
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 63-250 | p53 DNA-binding | ||||
Sequence: TDYPGDYGFKLQFPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDFAPPQGSVLRATAIYKKSEHVAEVVRRCPHHERTPDTDGLAPPAHLIRVEGNLRAIYKVDDITSRHSVMVLYEAPQLGAGFTTVLYNYMCNSSCMGGMNRRPILTIITLETQDGQMLGRRSFEVRVCACPGRDRKTEESN | ||||||
Compositional bias | 245-259 | Basic and acidic residues | ||||
Sequence: KTEESNFRKDQETKT | ||||||
Region | 245-292 | Disordered | ||||
Sequence: KTEESNFRKDQETKTMSKTPSTTKRGMIKESTMSRPEGSKRAKLSASS | ||||||
Compositional bias | 274-291 | Basic and acidic residues | ||||
Sequence: ESTMSRPEGSKRAKLSAS | ||||||
Domain | 289-324 | p53 tetramerisation | ||||
Sequence: SASSDEEIYTLQVKGKERFDMLKKINDSLELTDVVP | ||||||
Region | 334-366 | Disordered | ||||
Sequence: KLLSKSKKERDGQTPEPKRGKKLMVKDEKSDSD |
Sequence similarities
Belongs to the p53 family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length366
- Mass (Da)41,119
- Last updated2017-07-05 v1
- Checksum92F05CD9DD61B1F9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 245-259 | Basic and acidic residues | ||||
Sequence: KTEESNFRKDQETKT | ||||||
Compositional bias | 274-291 | Basic and acidic residues | ||||
Sequence: ESTMSRPEGSKRAKLSAS |