A0A1W6BQF7 · A0A1W6BQF7_GOBRA

Function

function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for site, binding site.

136650100150200250300350
TypeIDPosition(s)Description
Site82Interaction with DNA
Binding site138Zn2+ (UniProtKB | ChEBI)
Binding site141Zn2+ (UniProtKB | ChEBI)
Binding site200Zn2+ (UniProtKB | ChEBI)
Binding site204Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionDNA-binding transcription factor activity
Molecular Functionmetal ion binding
Molecular Functiontranscription cis-regulatory region binding
Biological Processanatomical structure morphogenesis
Biological Processapoptotic process
Biological Processepithelium development
Biological Processprotein tetramerization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Cellular tumor antigen p53

Gene names

    • Name
      p53

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Gobionidae > Sarcocheilichthyinae > Gobiocypris

Accessions

  • Primary accession
    A0A1W6BQF7

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for cross-link.

TypeIDPosition(s)Description
Cross-link253Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords

Interaction

Subunit

Binds DNA as a homotetramer.

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain63-250p53 DNA-binding
Compositional bias245-259Basic and acidic residues
Region245-292Disordered
Compositional bias274-291Basic and acidic residues
Domain289-324p53 tetramerisation
Region334-366Disordered

Sequence similarities

Belongs to the p53 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    366
  • Mass (Da)
    41,119
  • Last updated
    2017-07-05 v1
  • Checksum
    92F05CD9DD61B1F9
MAENPESQEFADLWERNLISAPEGSPWDINDEYPPFDPSIFNLISEQSQPSTSPPTSTVPIATDYPGDYGFKLQFPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDFAPPQGSVLRATAIYKKSEHVAEVVRRCPHHERTPDTDGLAPPAHLIRVEGNLRAIYKVDDITSRHSVMVLYEAPQLGAGFTTVLYNYMCNSSCMGGMNRRPILTIITLETQDGQMLGRRSFEVRVCACPGRDRKTEESNFRKDQETKTMSKTPSTTKRGMIKESTMSRPEGSKRAKLSASSDEEIYTLQVKGKERFDMLKKINDSLELTDVVPPCDVEKYRQKLLSKSKKERDGQTPEPKRGKKLMVKDEKSDSD

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias245-259Basic and acidic residues
Compositional bias274-291Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KX018989
EMBL· GenBank· DDBJ
ARJ54144.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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