A0A1W5XLY8 · A0A1W5XLY8_9ACTN

  • Protein
    Thiazole synthase
  • Gene
    thiG
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for active site, binding site.

128120406080100120140160180200220240260280
TypeIDPosition(s)Description
Active site115Schiff-base intermediate with DXP
Binding site1761-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site202-2031-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)
Binding site224-2251-deoxy-D-xylulose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionthiazole synthase activity
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Thiazole synthase
  • EC number

Gene names

    • Name
      thiG
    • ORF names
      STRMOE7_11355

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MOE7
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A1W5XLY8

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer. Forms heterodimers with either ThiH or ThiS.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-20Disordered
Domain24-267Thiazole synthase ThiG
Region262-281Disordered

Sequence similarities

Belongs to the ThiG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    281
  • Mass (Da)
    29,074
  • Last updated
    2017-07-05 v1
  • Checksum
    9300758002672061
MPDSALLADTPAAGGSAPATDPLTIAGTTFGSRLIMGTGGAPSLDVMERALLASGTELTTVAMRRLDPTVQGSVLSVLQRHKIRVLPNTAGCFTAGEAVLTARLAREALGTDWVKLEVVADERTLLPDPVELLDAAETLVDDGFTVLPYTNDDPVLARKLEEVGCAAIMPLGSPIGSGLGIRNPHNFQLITERAGVPVILDAGAGTASDAALAMELGCAAVMLASAVTRAQEPELMAHAMRHAVAAGRLAHRAGRIPRRHFAVASSPSEGTPALDPERPAF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP019779
EMBL· GenBank· DDBJ
ARH90815.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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