A0A1W5XLR1 · A0A1W5XLR1_9ACTN

  • Protein
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
  • Gene
    murF
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.

Catalytic activity

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Features

Showing features for binding site.

148050100150200250300350400450
TypeIDPosition(s)Description
Binding site109-115ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionUDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Molecular FunctionUDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
  • EC number
  • Alternative names
    • D-alanyl-D-alanine-adding enzyme

Gene names

    • Name
      murF
    • ORF names
      STRMOE7_11235

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MOE7
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A1W5XLR1

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain32-81Mur ligase N-terminal catalytic
Domain108-297Mur ligase central
Domain321-453Mur ligase C-terminal

Sequence similarities

Belongs to the MurCDEF family. MurF subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    480
  • Mass (Da)
    49,607
  • Last updated
    2017-07-05 v1
  • Checksum
    D5E68FD0813DEFDA
MISLSLAEIASIVGGQQHDIPDADRLVTGPVVTDSRAVRPGGLFVAFAGERADGHDFAPGAVEAGAVAVLAARPVGVPAIVVHDVTAALGALARAVVERLGTTVVGLTGSAGKTSTKDLIAQLLQRHGPTVWPEGNLNNEIGLPLTALRADATTRHLVLEMGARGIGHIRYLATLTPPRIGVVLNVGSAHIGEFGGRAQIAQAKGELVEALPSAEEGGIAVLNADDPYVRAMAPRTKARTVLFGEAEDAAVRAENVRLTDLGQPAFTLHTPSGCSDVTMRLYGEHHVSNALAAAAVAHELGMPVDEIATALSEAGTLSRWRMEVTERADGVTVVNDAYNANPESMRAALRALVAMGAAGKAEGGRTWAVLGEMAELGEESLAEHDAVGRLVVRLNVSKLVAVGGREAAWLDMGAKNEGSWGEESVHVSDARAAVDLLRSELRPGDVVLVKASRSVGLERVAAALLDDEGVMGAEGGAASR

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP019779
EMBL· GenBank· DDBJ
ARH90794.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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