A0A1W5KJW8 · A0A1W5KJW8_HUMAN
- ProteinAmine oxidase [flavin-containing] A
- GeneMAOA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids
- Protein existenceInferred from homology
- Annotation score4/5
Function
Catalytic activity
- (R)-adrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + methylamine
- (R)-noradrenaline + H2O + O2 = (R)-3,4-dihydroxymandelaldehyde + H2O2 + NH4+
- 2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4+
- H2O + O2 + serotonin = (5-hydroxyindol-3-yl)acetaldehyde + H2O2 + NH4+
- H2O + O2 + tryptamine = H2O2 + indole-3-acetaldehyde + NH4+
- H2O + O2 + tyramine = (4-hydroxyphenyl)acetaldehyde + H2O2 + NH4+
- H2O + kynuramine + O2 = 3-(2-aminophenyl)-3-oxopropanal + H2O2 + NH4+This reaction proceeds in the forward direction.
- dopamine + H2O + O2 = 3,4-dihydroxyphenylacetaldehyde + H2O2 + NH4+
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial outer membrane | |
Molecular Function | flavin adenine dinucleotide binding | |
Molecular Function | primary amine oxidase activity | |
Biological Process | catecholamine metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAmine oxidase [flavin-containing] A
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A1W5KJW8
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion outer membrane ; Single-pass type IV membrane protein
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Interaction
Subunit
Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.
Structure
Sequence
- Sequence statusFragment
- Length53
- Mass (Da)6,280
- Last updated2017-07-05 v1
- ChecksumBB47952BBA3E5A7B
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: C | ||||||
Non-terminal residue | 53 | |||||
Sequence: K |