A0A1W5G6R8 · A0A1W5G6R8_9PRIM

  • Protein
    NADH-ubiquinone oxidoreductase chain 4
  • Gene
    ND4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex I
Molecular FunctionNADH dehydrogenase (ubiquinone) activity
Molecular FunctionNADH dehydrogenase activity
Molecular Functionubiquinone binding
Biological ProcessATP synthesis coupled electron transport
Biological Processelectron transport coupled proton transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NADH-ubiquinone oxidoreductase chain 4
  • EC number

Gene names

    • Name
      ND4

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • FAN6.1
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Strepsirrhini > Lemuriformes > Lepilemuridae > Lepilemur

Accessions

  • Primary accession
    A0A1W5G6R8

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein
Mitochondrion membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane21-42Helical
Transmembrane62-82Helical
Transmembrane94-110Helical
Transmembrane116-133Helical
Transmembrane145-167Helical
Transmembrane193-212Helical
Transmembrane224-244Helical
Transmembrane256-277Helical
Transmembrane284-303Helical
Transmembrane309-329Helical
Transmembrane350-368Helical
Transmembrane388-409Helical

Keywords

Interaction

Subunit

Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-109NADH:ubiquinone oxidoreductase chain 4 N-terminal
Domain113-397NADH:quinone oxidoreductase/Mrp antiporter membrane subunit

Sequence similarities

Belongs to the complex I subunit 4 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    459
  • Mass (Da)
    51,793
  • Last updated
    2017-07-05 v1
  • Checksum
    82D7A865C26FAF19
MLKIIVPTAMLLPVIWYSTNPMTWMNITLHSLTISLMSLFLFSQADTNSNNFSPTFFSDPLSSPLLVLTMWLLPLTVVASQYHLTKEPWERKKHFLSTLISLQLLLVMTFATTELIMFYILFESTLIPTLVIITRWGNQTERLNAGLYFLFYTLTGSLPLLVALSYIQSSMGTLNLFMMTYWLQELPNSWSNYLLWTACIMAFMIKMPLYGLHMWLPKAHVEAPIAGSMILAAILLKLGGYGMMRITMILNPLTKSMAYPFLMLCLWGMIMTSLICLRQTDLKSLIAYSSVSHMALVIVAILIQTPWSLMGATTLMIAHGLTSSVLFCLANSNYERVHSRTMLLARGLQALLPLMSTWWLLASLSNLALPPSINLIGELLVTMAAFSWSNTTIILTGLNMLVTATYSLYMLTTTQRGKSPYHMQNFSPSLTRENTLMSMHILPLLLLTLNPKILMGPTY

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ171066
EMBL· GenBank· DDBJ
ADP68202.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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