A0A1W2PQV5 · A0A1W2PQV5_HUMAN

  • Protein
    Hydroxyacyl-CoA dehydrogenase
  • Gene
    HADH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

Pathway

Lipid metabolism.

Features

Showing features for binding site, site.

124520406080100120140160180200220240
TypeIDPosition(s)Description
Binding site73CoA (UniProtKB | ChEBI)
Binding site80CoA (UniProtKB | ChEBI)
Binding site149CoA (UniProtKB | ChEBI)
Site170Important for catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionNAD+ binding
Molecular Functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Processfatty acid metabolic process

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • Hydroxyacyl-CoA dehydrogenase

Gene names

    • Name
      HADH

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1W2PQV5

Proteomes

Organism-specific databases

Disease & Variants

Variants

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The viewer provides 239 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)13PRIDEPhosphoserine
Modified residue (large scale data)73PRIDEPhosphoserine

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-2143-hydroxyacyl-CoA dehydrogenase NAD binding

Sequence similarities

Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    245
  • Mass (Da)
    26,480
  • Last updated
    2017-06-07 v1
  • Checksum
    E475B138370911D1
MAFVTRQFMRSVSSSSTASASAKKIIVKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLRKVAKKKFAENLKAGDEFVEKTLSTIATSTDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFAAEHTIFASNTSSLQITSIANATTRQDRFAGLHFFNPVPVMKLVEVIKTPMTSQKTFESLVDFSKALGKHPVSCKDTPGFIVNRLLVPYLMEAIRLYERGPPGFPVGL

Computationally mapped potential isoform sequences

There are 16 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q16836HCDH_HUMANHADH314
J3KR89J3KR89_HUMANHADH52
A0A1W2PP40A0A1W2PP40_HUMANHADH145
A0A1W2PQ55A0A1W2PQ55_HUMANHADH100
A0A1W2PQ78A0A1W2PQ78_HUMANHADH176
A0A1W2PNM1A0A1W2PNM1_HUMANHADH267
A0A1W2PQC2A0A1W2PQC2_HUMANHADH165
A0A1W2PRT2A0A1W2PRT2_HUMANHADH183
A0A1W2PRM6A0A1W2PRM6_HUMANHADH22
A0A0D9SFP2A0A0D9SFP2_HUMANHADH318
A0A0A0MSE2A0A0A0MSE2_HUMANHADH317
A0A804HLB5A0A804HLB5_HUMANHADH201
A0A804HJW7A0A804HJW7_HUMANHADH245
A0A804HJK7A0A804HJK7_HUMANHADH132
A0A804HKJ2A0A804HKJ2_HUMANHADH249
E9PF18E9PF18_HUMANHADH390

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC114733
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC118062
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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