A0A1W2PPX7 · A0A1W2PPX7_HUMAN

  • Protein
    Calcium-activated potassium channel subunit alpha-1
  • Gene
    KCNMA1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functionligand-gated monoatomic cation channel activity
Molecular Functionmonoatomic ion-gated channel activity
Molecular Functionpotassium channel activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Calcium-activated potassium channel subunit alpha-1
  • Alternative names
    • BK channel
    • BKCA alpha
    • Calcium-activated potassium channel, subfamily M subunit alpha-1
    • K(VCA)alpha
    • KCa1.1

Gene names

    • Name
      KCNMA1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1W2PPX7

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane86-108Helical
Transmembrane179-197Helical
Transmembrane217-235Helical
Transmembrane300-321Helical
Transmembrane336-355Helical
Transmembrane367-385Helical

Keywords

  • Cellular component

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,216 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Features

Showing features for modified residue (large scale data).

TypeIDPosition(s)SourceDescription
Modified residue (large scale data)1095PRIDEPhosphothreonine
Modified residue (large scale data)1212PRIDEPhosphoserine

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

TypeIDPosition(s)Description
Region1-61Disordered
Compositional bias21-61Polar residues
Domain181-396Ion transport
Domain546-633Calcium-activated potassium channel BK alpha subunit
Region764-794Disordered
Compositional bias773-791Polar residues
Domain1063-1183Ca2+-activated K+ channel Slowpoke-like C-terminal
Compositional bias1193-1224Polar residues
Region1193-1242Disordered
Compositional bias1225-1242Basic and acidic residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,242
  • Mass (Da)
    138,356
  • Last updated
    2017-06-07 v1
  • Checksum
    F076A09ED2172261
MANGGGGGGGSSGGGGGGGGSSLRMSSNIHANHLSLDASSSSSSSSSSSSSSSSSSSSSSVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCCHCGGKTKEAQKINNGSSQADGTLKPVDEKEEAVAAEVGWMTSVKDWAGVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQEGTLGFFIASDAKEVKRAFFYCKACHDDITDPKRIKKCGCKRLIYSKMSIYKRMRRACCFDCGRSERDCSCMSGRVRGNVDTLERAFPLSSVSVNDCSTSFRAFEDEQPSTLSPKKKQRNGGMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLMSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFELVPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRQNRPKSRESRDKQKKEMVYR

Computationally mapped potential isoform sequences

There are 70 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q12791KCMA1_HUMANKCNMA11236
J3KQ16J3KQ16_HUMANKCNMA11040
B7ZMF5B7ZMF5_HUMANKCNMA11208
D5MRH1D5MRH1_HUMANKCNMA11128
A0A1B0GWD4A0A1B0GWD4_HUMANKCNMA1459
A0A1W2PP76A0A1W2PP76_HUMANKCNMA130
A0A1W2PP94A0A1W2PP94_HUMANKCNMA11181
A0A1W2PP06A0A1W2PP06_HUMANKCNMA11223
A0A1W2PP26A0A1W2PP26_HUMANKCNMA11198
A0A1W2PP37A0A1W2PP37_HUMANKCNMA199
Q5SVJ7Q5SVJ7_HUMANKCNMA11209
Q5SVJ8Q5SVJ8_HUMANKCNMA11288
Q5SVJ9Q5SVJ9_HUMANKCNMA11235
Q5SVK0Q5SVK0_HUMANKCNMA11195
Q5SVK5Q5SVK5_HUMANKCNMA11232
A0A1W2PPY5A0A1W2PPY5_HUMANKCNMA11230
A0A1W2PPZ1A0A1W2PPZ1_HUMANKCNMA11238
A0A1W2PQ93A0A1W2PQ93_HUMANKCNMA11197
A0A1W2PPQ3A0A1W2PPQ3_HUMANKCNMA11178
A0A1W2PPS2A0A1W2PPS2_HUMANKCNMA11122
A0A1W2PQ39A0A1W2PQ39_HUMANKCNMA1583
A0A1W2PPT7A0A1W2PPT7_HUMANKCNMA1422
A0A1W2PQ53A0A1W2PQ53_HUMANKCNMA11115
A0A1W2PQ61A0A1W2PQ61_HUMANKCNMA11181
A0A1W2PPH9A0A1W2PPH9_HUMANKCNMA11175
A0A1W2PNW6A0A1W2PNW6_HUMANKCNMA11230
A0A1W2PNX9A0A1W2PNX9_HUMANKCNMA1575
A0A1W2PNY7A0A1W2PNY7_HUMANKCNMA11161
A0A1W2PNY8A0A1W2PNY8_HUMANKCNMA11020
A0A1W2PNY9A0A1W2PNY9_HUMANKCNMA11233
A0A1W2PNN5A0A1W2PNN5_HUMANKCNMA1154
A0A1W2PNN6A0A1W2PNN6_HUMANKCNMA1100
A0A1W2PNQ3A0A1W2PNQ3_HUMANKCNMA11177
H0Y379H0Y379_HUMANKCNMA11192
H0Y382H0Y382_HUMANKCNMA11182
A0A1W2PNG1A0A1W2PNG1_HUMANKCNMA11146
H0Y406H0Y406_HUMANKCNMA1208
A0A1W2PNH9A0A1W2PNH9_HUMANKCNMA11181
A0A1W2PSD3A0A1W2PSD3_HUMANKCNMA11178
A0A1W2PQZ4A0A1W2PQZ4_HUMANKCNMA1357
A0A1W2PQZ8A0A1W2PQZ8_HUMANKCNMA1403
A0A1W2PRA7A0A1W2PRA7_HUMANKCNMA1964
A0A1W2PQR1A0A1W2PQR1_HUMANKCNMA1584
A0A1W2PR56A0A1W2PR56_HUMANKCNMA11212
A0A1W2PQU4A0A1W2PQU4_HUMANKCNMA11178
A0A1W2PR62A0A1W2PR62_HUMANKCNMA11236
A0A1W2PQJ9A0A1W2PQJ9_HUMANKCNMA11119
A0A1W2PQK5A0A1W2PQK5_HUMANKCNMA11177
A0A1W2PQA0A0A1W2PQA0_HUMANKCNMA11234
A0A1W2PSA7A0A1W2PSA7_HUMANKCNMA178
A0A1W2PRT6A0A1W2PRT6_HUMANKCNMA1383
A0A1W2PS54A0A1W2PS54_HUMANKCNMA1190
A0A1W2PRJ1A0A1W2PRJ1_HUMANKCNMA1977
A0A1W2PRV4A0A1W2PRV4_HUMANKCNMA11246
A0A1W2PRX6A0A1W2PRX6_HUMANKCNMA11196
A0A1W2PS97A0A1W2PS97_HUMANKCNMA11142
A0A1W2PRN5A0A1W2PRN5_HUMANKCNMA11239
A0A1W2PRB0A0A1W2PRB0_HUMANKCNMA11234
A0A1W2PRC3A0A1W2PRC3_HUMANKCNMA197
A0A1W2PRE5A0A1W2PRE5_HUMANKCNMA11185
A0A1W2PRF1A0A1W2PRF1_HUMANKCNMA191
A0A1W2PRG5A0A1W2PRG5_HUMANKCNMA11208
A0A0A0MRR0A0A0A0MRR0_HUMANKCNMA11233
A0A9L9PYL6A0A9L9PYL6_HUMANKCNMA1512
A0A0A0MSE6A0A0A0MSE6_HUMANKCNMA11142
A0A9L9PXP1A0A9L9PXP1_HUMANKCNMA11084
A0A0A0MRC3A0A0A0MRC3_HUMANKCNMA11071
S4R453S4R453_HUMANKCNMA1128
S4R2X4S4R2X4_HUMANKCNMA11043
A0A087WZL8A0A087WZL8_HUMANKCNMA1213

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias21-61Polar residues
Compositional bias773-791Polar residues
Compositional bias1193-1224Polar residues
Compositional bias1225-1242Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC011439
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC021032
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC067745
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL157833
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL607069
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL627447
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL731556
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL731560
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL731575
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp