A0A1W2PPB6 · A0A1W2PPB6_HUMAN

  • Protein
    GPI ethanolamine phosphate transferase 1
  • Gene
    PIGN
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionmannose-ethanolamine phosphotransferase activity
Biological ProcessGPI anchor biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GPI ethanolamine phosphate transferase 1
  • EC number

Gene names

    • Name
      PIGN

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1W2PPB6

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane441-463Helical
Transmembrane483-500Helical
Transmembrane506-523Helical
Transmembrane532-551Helical
Transmembrane563-581Helical
Transmembrane593-611Helical
Transmembrane617-638Helical
Transmembrane650-668Helical
Transmembrane680-701Helical
Transmembrane713-737Helical

Keywords

Disease & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 800 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Genetic variation databases

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain430-727GPI ethanolamine phosphate transferase 1 C-terminal

Sequence similarities

Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    738
  • Mass (Da)
    83,562
  • Last updated
    2017-06-07 v1
  • Checksum
    D0786449DD579012
MLLFFTLGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPARRLVLFVADGLRADALYELDENGNSRAPFIRNIIMHEGSWGISHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAKREDFGAQDATKLDTWVFDNVKDFFHHARNNQSLFSKINEEKIVFFLHLLGIDTNGHAHRPSSRDYKHNIKKVDDGVKEIVSMFNHFYGNDGKTTFIFTSDHGMTDWGSHGAGHPSETLTPLVTWGAGIKYPQRVSAQQFDDAFLKEWRLENWKRLDVNQADIAPLMTSLIGVPFPLNSVGILPVDYLNNTDLFKAESMFTNAVQILEQFKVKMTQKKEVTLPFLFTPFKLLSDSKQFNILRKARSYIKHRKFDEVVSLCKELIHLALKGLSYYHTYDRFFLGVNVVIGFVGWISYASLLIIKSHSNLIKGVSKEVKKPSHLLPCSFVAIGILVAFFLLIQACPWTYYVYGLLPLPIWYAVLREFQVIQDLVVSVLTYPLSHFVGYLLAFTLGIEVLVLSFFYRYMLTAGLTAFAAWPFLTRLWTRAKMTSLSWTFFSLLLAVFPLMPVVGRKPDISLVMGAGLLVLLLSLCVVTSLMKRKDSFIKEELLVHLLQVLSTVLSMYVVYSTQSSLLRKQGLPLMNQIISWATLASSLVVPLLSSPVLFQRLFSILLSLMSTYLLLSTGSPVSSSLIILI

Computationally mapped potential isoform sequences

There are 26 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
O95427PIGN_HUMANPIGN931
K7EID9K7EID9_HUMANPIGN140
A0A1W2PPR7A0A1W2PPR7_HUMANPIGN797
A0A1W2PQ49A0A1W2PQ49_HUMANPIGN184
A0A1W2PPK6A0A1W2PPK6_HUMANPIGN246
A0A1W2PPA0A0A1W2PPA0_HUMANPIGN525
A0A1W2PNW5A0A1W2PNW5_HUMANPIGN621
A0A1W2PNQ8A0A1W2PNQ8_HUMANPIGN847
A0A1W2PNR0A0A1W2PNR0_HUMANPIGN897
A0A1W2PNH8A0A1W2PNH8_HUMANPIGN911
A0A1W2PQZ1A0A1W2PQZ1_HUMANPIGN798
A0A1W2PQR8A0A1W2PQR8_HUMANPIGN854
A0A1W2PR74A0A1W2PR74_HUMANPIGN751
A0A1W2PQP4A0A1W2PQP4_HUMANPIGN870
A0A1W2PQA9A0A1W2PQA9_HUMANPIGN970
A0A1W2PS19A0A1W2PS19_HUMANPIGN936
A0A1W2PRH3A0A1W2PRH3_HUMANPIGN375
K7EJM6K7EJM6_HUMANPIGN143
K7ELE1K7ELE1_HUMANPIGN490
K7EL34K7EL34_HUMANPIGN283
K7EMD7K7EMD7_HUMANPIGN395
K7ENK2K7ENK2_HUMANPIGN70
K7EPJ2K7EPJ2_HUMANPIGN391
K7EQG0K7EQG0_HUMANPIGN138
K7ERX5K7ERX5_HUMANPIGN83
K7ESH9K7ESH9_HUMANPIGN198

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC090354
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC090396
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC105183
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
FP340563
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF456430
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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