A0A1W2PNF7 · A0A1W2PNF7_HUMAN

  • Protein
    Elongator complex protein 4
  • Gene
    ELP4
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.

Pathway

tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentelongator holoenzyme complex
Cellular Componentnucleus
Biological ProcesstRNA wobble uridine modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Elongator complex protein 4

Gene names

    • Name
      ELP4

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1W2PNF7

Proteomes

Organism-specific databases

Subcellular Location

Disease & Variants

Genetic variation databases

PTM/Processing

Expression

Gene expression databases

Family & Domains

Sequence similarities

Belongs to the ELP4 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    128
  • Mass (Da)
    13,768
  • Last updated
    2017-06-07 v1
  • Checksum
    F8AB5AF12767F8A4
XSIAGTRPSVRNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQIKKELFLVSLLIRVLLCHPGWSAVAQSWLTAAPASRTQEIFPPQPPK

Computationally mapped potential isoform sequences

There are 21 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q96EB1ELP4_HUMANELP4424
A0A1X7SBS0A0A1X7SBS0_HUMANELP4425
A0A1W2PP47A0A1W2PP47_HUMANELP4359
A0A1W2PP49A0A1W2PP49_HUMANELP4138
A0A1W2PQ05A0A1W2PQ05_HUMANELP4131
A0A1W2PPP6A0A1W2PPP6_HUMANELP4424
A0A1W2PPR3A0A1W2PPR3_HUMANELP4101
A0A1W2PNW2A0A1W2PNW2_HUMANELP4234
A0A1W2PNY4A0A1W2PNY4_HUMANELP458
A0A1W2PNY5A0A1W2PNY5_HUMANELP4386
A0A1W2PQZ6A0A1W2PQZ6_HUMANELP4392
A0A1W2PQW5A0A1W2PQW5_HUMANELP471
A0A1W2PR08A0A1W2PR08_HUMANELP4450
A0A1W2PQA7A0A1W2PQA7_HUMANELP4265
A0A1W2PS44A0A1W2PS44_HUMANELP4131
A0A1W2PRJ0A0A1W2PRJ0_HUMANELP4396
A0A1W2PS93A0A1W2PS93_HUMANELP4425
A0A1W2PRF0A0A1W2PRF0_HUMANELP4395
A0A1W2PRF5A0A1W2PRF5_HUMANELP4475
E9PPJ9E9PPJ9_HUMANELP4185
G5E9D4G5E9D4_HUMANELP4535

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC108456
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC131571
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
KF510367
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
Z83001
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
Z83306
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
Z83307
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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