A0A1W2PNF7 · A0A1W2PNF7_HUMAN
- ProteinElongator complex protein 4
- GeneELP4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids128 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Pathway
tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | elongator holoenzyme complex | |
Cellular Component | nucleus | |
Biological Process | tRNA wobble uridine modification |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameElongator complex protein 4
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A1W2PNF7
Proteomes
Organism-specific databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusFragment
- Length128
- Mass (Da)13,768
- Last updated2017-06-07 v1
- ChecksumF8AB5AF12767F8A4
Computationally mapped potential isoform sequences
There are 21 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q96EB1 | ELP4_HUMAN | ELP4 | 424 | ||
A0A1X7SBS0 | A0A1X7SBS0_HUMAN | ELP4 | 425 | ||
A0A1W2PP47 | A0A1W2PP47_HUMAN | ELP4 | 359 | ||
A0A1W2PP49 | A0A1W2PP49_HUMAN | ELP4 | 138 | ||
A0A1W2PQ05 | A0A1W2PQ05_HUMAN | ELP4 | 131 | ||
A0A1W2PPP6 | A0A1W2PPP6_HUMAN | ELP4 | 424 | ||
A0A1W2PPR3 | A0A1W2PPR3_HUMAN | ELP4 | 101 | ||
A0A1W2PNW2 | A0A1W2PNW2_HUMAN | ELP4 | 234 | ||
A0A1W2PNY4 | A0A1W2PNY4_HUMAN | ELP4 | 58 | ||
A0A1W2PNY5 | A0A1W2PNY5_HUMAN | ELP4 | 386 | ||
A0A1W2PQZ6 | A0A1W2PQZ6_HUMAN | ELP4 | 392 | ||
A0A1W2PQW5 | A0A1W2PQW5_HUMAN | ELP4 | 71 | ||
A0A1W2PR08 | A0A1W2PR08_HUMAN | ELP4 | 450 | ||
A0A1W2PQA7 | A0A1W2PQA7_HUMAN | ELP4 | 265 | ||
A0A1W2PS44 | A0A1W2PS44_HUMAN | ELP4 | 131 | ||
A0A1W2PRJ0 | A0A1W2PRJ0_HUMAN | ELP4 | 396 | ||
A0A1W2PS93 | A0A1W2PS93_HUMAN | ELP4 | 425 | ||
A0A1W2PRF0 | A0A1W2PRF0_HUMAN | ELP4 | 395 | ||
A0A1W2PRF5 | A0A1W2PRF5_HUMAN | ELP4 | 475 | ||
E9PPJ9 | E9PPJ9_HUMAN | ELP4 | 185 | ||
G5E9D4 | G5E9D4_HUMAN | ELP4 | 535 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC108456 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC131571 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
KF510367 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
Z83001 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
Z83306 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
Z83307 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |