As the more efficient utrophin-based response in mdx skeletal muscle appears to involve independent transcriptional activation of conserved myogenic isoforms (A' and F) elevating their paralogues in DMD patients is an encouraging therapeutic strategy.
Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.
at dystrophin levels < 4% survival and motor function are greatly improved in a mdx/utrn-deficient model which expresses a range of low dystrophin levels depending on the degree of skewing of X inactivation in a utrophin-negative background
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