A0A1W2KEI3 · A0A1W2KEI3_9TELE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • DYBYZ2
    • DYBYZ4
    • DYCYZ1
    • DYCYZ3
    • DYCYZ5
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Eupercaria > Sillaginidae > Sillago

Accessions

  • Primary accession
    A0A1W2KEI3

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane34-59Helical
Transmembrane80-104Helical
Transmembrane124-147Helical
Transmembrane159-186Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-194Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    194
  • Mass (Da)
    20,582
  • Last updated
    2017-06-07 v1
  • Checksum
    DE436B04A5264C15
WAGMVGTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPILIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPATSQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTT

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue194

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KU051907
EMBL· GenBank· DDBJ
ANP23601.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051908
EMBL· GenBank· DDBJ
ANP23602.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051909
EMBL· GenBank· DDBJ
ANP23603.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051910
EMBL· GenBank· DDBJ
ANP23604.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051911
EMBL· GenBank· DDBJ
ANP23605.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051912
EMBL· GenBank· DDBJ
ANP23606.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051913
EMBL· GenBank· DDBJ
ANP23607.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051914
EMBL· GenBank· DDBJ
ANP23608.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051915
EMBL· GenBank· DDBJ
ANP23609.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051916
EMBL· GenBank· DDBJ
ANP23610.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051917
EMBL· GenBank· DDBJ
ANP23611.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051919
EMBL· GenBank· DDBJ
ANP23613.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051920
EMBL· GenBank· DDBJ
ANP23614.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051921
EMBL· GenBank· DDBJ
ANP23615.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051922
EMBL· GenBank· DDBJ
ANP23616.1
EMBL· GenBank· DDBJ
Genomic DNA
KU051923
EMBL· GenBank· DDBJ
ANP23617.1
EMBL· GenBank· DDBJ
Genomic DNA
MF571926
EMBL· GenBank· DDBJ
AUW64531.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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