A0A1W2H112 · A0A1W2H112_9BACT

Function

function

Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 Mn2+ ion per subunit.

Pathway

Carbohydrate biosynthesis; gluconeogenesis.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site71substrate
Binding site209-211substrate
Binding site218Mn2+ (UniProtKB | ChEBI)
Binding site238Mn2+ (UniProtKB | ChEBI)
Binding site260substrate
Binding site261-266GTP (UniProtKB | ChEBI)
Active site262
Binding site287Mn2+ (UniProtKB | ChEBI)
Binding site377-379substrate
Binding site379GTP (UniProtKB | ChEBI)
Binding site410GTP (UniProtKB | ChEBI)
Binding site503-506GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular Functionkinase activity
Molecular Functionmanganese ion binding
Molecular Functionphosphoenolpyruvate carboxykinase (GTP) activity
Biological Processcellular response to glucose stimulus
Biological Processgluconeogenesis
Biological Processglycerol biosynthetic process from pyruvate
Biological Processphosphorylation
Biological Processpropionate catabolic process
Biological Processresponse to lipid
Biological Processresponse to starvation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoenolpyruvate carboxykinase [GTP]
  • EC number
  • Short names
    PEP carboxykinase
    ; PEPCK
  • Alternative names
    • GTP-dependent phosphoenolpyruvate carboxykinase
      (GTP-PEPCK
      )

Gene names

    • Name
      pckG
    • ORF names
      SAMN00777080_1131

Organism names

  • Taxonomic identifier
  • Strain
    • DSM 16537
  • Taxonomic lineage
    Bacteria > Bacteroidota > Cytophagia > Cytophagales > Cyclobacteriaceae > Aquiflexum

Accessions

  • Primary accession
    A0A1W2H112

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-230Phosphoenolpyruvate carboxykinase GTP-utilising N-terminal
Domain234-585Phosphoenolpyruvate carboxykinase C-terminal P-loop

Sequence similarities

Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    608
  • Mass (Da)
    68,795
  • Last updated
    2017-06-07 v1
  • Checksum
    C6C1F879C6185A99
MISTIKTELKSWVESMADHFKPEKTYWCDGSQEEYDTLCQLMVDKGTFIKLNPKKRPNSFACFSDPSDVARVEDKTFICSRRKEDAGPTNNWMSPSDMKTILDDLTKGSMKGRTMYVIPFCMGPLGSPLSRYGVQITDSEYVVVNMRIMTRMGNQAIPYIDENFVKCIHTLGAPLADGQEDVKWPCNPNVKYISHFPEEKLIISYGSGYGGNALLGKKCFALRIASTMGREEGWLAEHMLIMGVESPQNEKSYVAAAFPSACGKTNFAMMVPPEELEGWKITTVGDDIAWIHKGKDGKLHAINPEAGYFGVAPGTNYNTNPSAMESIKENTIFTNVAITKDGDVWWEGMTKEVPDGLTDWHGKPYDKNSGKPAAHANSRFTAPAYQNPVIDPEWDNPEGVPITAFIFGGRRSTAVPLVYQAFNWNFGVYMAATMGSEMTAAAFGEIGKVRRDPFAMLPFMGYHMGDYFNHWLQFGRDLENAPRIFGVNWFRKDKEGNFIWPGFGDNMRVLKWIIGRCKGKISAVECPIGWRPRYKDMDWNGLESFTRDDFNNIMIIETEPWKAEMLGHSELFEKAYDKIPKEFLFMRELLLSALWRSPEKIGLAPERH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LT838813
EMBL· GenBank· DDBJ
SMD42571.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp