A0A1W1YVW2 · A0A1W1YVW2_9PSED

Function

function

Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.

Catalytic activity

Pathway

Bacterial outer membrane biogenesis; LPS core biosynthesis.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site194-197ATP (UniProtKB | ChEBI)
Active site263

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functionheptose 7-phosphate kinase activity
Molecular Functionheptose-1-phosphate adenylyltransferase activity
Molecular Functionphosphotransferase activity, alcohol group as acceptor
Biological ProcessADP-L-glycero-beta-D-manno-heptose biosynthetic process
Biological Processlipopolysaccharide core region biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein HldE

Including 2 domains:

  • Recommended name
    D-beta-D-heptose 7-phosphate kinase
  • EC number
  • Alternative names
    • D-beta-D-heptose 7-phosphotransferase
    • D-glycero-beta-D-manno-heptose-7-phosphate kinase
  • Recommended name
    D-beta-D-heptose 1-phosphate adenylyltransferase
  • EC number
  • Alternative names
    • D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase

Gene names

    • Name
      hldE
    • ORF names
      SAMN05660385_00610

Organism names

  • Taxonomic identifier
  • Strain
    • URIL14HWK12:I5
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A1W1YVW2

Proteomes

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-317Ribokinase
Domain13-303Carbohydrate kinase PfkB
Domain343-437Cytidyltransferase-like
Region343-473Cytidylyltransferase

Sequence similarities

In the C-terminal section; belongs to the cytidylyltransferase family.
In the N-terminal section; belongs to the carbohydrate kinase PfkB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    473
  • Mass (Da)
    49,931
  • Last updated
    2017-06-07 v1
  • Checksum
    5A7460D4684F8D24
MKLSMPRFDQAPVLVVGDVMLDRYWHGGTSRISPEAPVPVVKVDQIEDRPGGAANVALNIAALGAPASLIGVTGQDEAADSLANSLQAAGVRSVFQRIAHQPTIVKLRVMSRHQQLLRIDFEEPFATDPLSLGAEVDSLLEGVKVLVLSDYGKGALKNHQSLIQAARAKGIPVLADPKGKDFSIYRGASLITPNLSEFETIVGRCADEAELVAKGVQLLQDLDLGALLVTRGEHGMTLLRTGQPALHLPARAREVFDVTGAGDTVISTLAAAIAAGEDLPHAVALANLAAGIVVGKLGTAAISAPELRRAIQREEGSERGVLGLEQLLLAIDDARAHKEKIVFTNGCFDILHAGHVTYLEQARAQGDRLIVAVNDDASVSRLKGPGRPINSVDRRMAVLAGLGAVDWVISFPEGTPENLLSQVKPDVLVKGGDYGIDQVVGADIVKAYGGTVKVLGLVENSSTTAIVEKIRKN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FWXQ01000001
EMBL· GenBank· DDBJ
SMC40222.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp