A0A1W1VTT4 · A0A1W1VTT4_9BACT

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

168150100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site218-225ATP (UniProtKB | ChEBI)
Binding site441Zn2+ (UniProtKB | ChEBI); catalytic
Active site442
Binding site445Zn2+ (UniProtKB | ChEBI); catalytic
Binding site517Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      SAMN00120144_2996

Organism names

Accessions

  • Primary accession
    A0A1W1VTT4

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane123-142Helical

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain210-350AAA+ ATPase
Region621-681Disordered
Compositional bias634-649Basic and acidic residues

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    681
  • Mass (Da)
    74,885
  • Last updated
    2017-06-07 v1
  • Checksum
    E56251549891D7B9
MQLLVLGGLVLFIFAMFYFNRSNSTTDINQQKFEQMLLAGDVRDVTLVNDRAVEVTLKPEAAKSAKYNDELSRRGPLTLEQGPQFAFRVVDGKTFKEDLDKIQTNLPREQQVGLNIDQRQDGYGLLSSWGLIILLMVGFWFLMRRMSGSGGPGGQIFNIGKSRAALFEGGDKVKITFKDVAGLEEAKEEVEEIVEFLRNPSKFTVLGGKIPKGALLVGPPGTGKTLMAKAVAGEADVPFFSLSGSDFVEMFVGVGAARVRDLFKQAKAKAPCIIFIDEIDAIGRSRSSGKMPGGNDERENTLNSLLVEMDGFGTDSGVIILAATNRPDTLDSALLRPGRFDRQISIDKPDINGRTQIFQVHLKPLTLGPDVDARKLAAQTPGFAGAEIANVCNEAALIAARRDKKMVTMQDFTDAVDRVIGGLEKKNKIISPNEKRIVAYHEAGHAIAGWFLEHADPLVKVSIVPRGVAALGYAQYLPREQFLYNTEQLTDEMCMALGGRAAEDLVFGKISTGALSDLERITKMAYSIVTMYGMNEKLGNISFYDSKGQNEYGFSKPYSEATSQMIDEEVRTIISDAYERTKALLTDRRHELEIVAKELLEKEVLLQDDLERLVGKRPYDTQTSYQAHMAGTDRSETLSERKNEHPIPLSDDLPESNLPGLDFGTDGGTEGRQDTPVGTTL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias634-649Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FWWW01000073
EMBL· GenBank· DDBJ
SMB96782.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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