A0A1W1USU0 · A0A1W1USU0_9PAST

Function

function

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site244substrate
Binding site273substrate
Binding site302substrate
Binding site338substrate
Binding site358-360substrate
Binding site399-402substrate
Binding site438substrate
Binding site442Zn2+ (UniProtKB | ChEBI)
Binding site465substrate
Binding site506Zn2+ (UniProtKB | ChEBI)
Binding site586[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site589[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site594[4Fe-4S] cluster (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functioncarbon-carbon lyase activity
Molecular Functionzinc ion binding
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphomethylpyrimidine synthase
  • EC number
  • Alternative names
    • Hydroxymethylpyrimidine phosphate synthase
      (HMP-P synthase
      ; HMP-phosphate synthase
      ; HMPP synthase
      )
    • Thiamine biosynthesis protein ThiC

Gene names

    • Name
      thiC
    • ORF names
      SAMN05660772_00702

Organism names

Accessions

  • Primary accession
    A0A1W1USU0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain32-113ThiC-associated

Sequence similarities

Belongs to the ThiC family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    639
  • Mass (Da)
    71,490
  • Last updated
    2017-06-07 v1
  • Checksum
    66D1AA024F03E3A4
MSDTTIYTETNSRRQKRTAAQQFINTLKGAHYPSSKRIYLQGSRADIQVPMREIQLSPTLIGGDKNNPQYEPNDAIPVYDTSGVYGDETQTINIAQGIKALREQWIAERQDTEVLSAVSSNYTQARLQDKALDELRFQLQRPARRAQAGKTVTQLHYARQGIITPEMEFIAIRENMGRARVQSAVLLQQHSGQAFGADLPAVITPEFVRQEVAAGRAIIPCNINHPESEPMIIGRNFLVKVNANIGNSAVTSSIEEEVEKLVWATRWGADTVMDLSTGRNIHETREWILRNSPVPIGTVPLYQALEKVKGIAENLSWEVFKDTLIEQAEQGVDYFTIHAGTLLRYVPMTAKRLTGIVSRGGSIMAKWCLSHHQENFLYRHFRDICEICAAYDVALSLGDGLRPGSIQDANDEAQFAELYTLGELTKIAWQYDVQVMIEGPGHIPMQMIRRNMTEELEHCHQAPFYTLGPLTTDIAPGYDHFTSGIGAALIGWFGCAMLCYVTPKEHLGLPDKDDVKQGLITYKIAAHAADLAKGHPAAQIRDNAMSKARFEFRWQDQFNLSLDPETAQAYHDETLPQESGKVAHFCSMCGPKFCSMKISQEVRDYAANLSSEQQAGLAEMSQQFKQKGGEIYHLPTDLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FWWV01000013
EMBL· GenBank· DDBJ
SMB83794.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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