A0A1V9QZS3 · A0A1V9QZS3_9LACO

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site9-14substrate
Binding site42Mg2+ (UniProtKB | ChEBI)
Active site71Proton acceptor
Binding site71Mg2+ (UniProtKB | ChEBI)
Binding site72substrate
Binding site153-156substrate
Binding site176substrate
Binding site181-182substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      B6U60_05445

Organism names

  • Taxonomic identifier
  • Strain
    • LMG 14477
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Ligilactobacillus

Accessions

  • Primary accession
    A0A1V9QZS3

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    199
  • Mass (Da)
    22,424
  • Last updated
    2017-06-07 v1
  • Checksum
    474E646342120DAB
MVKHILIATKNAGKVREFKKLFSEKGIEVKTLLDMENTPEIDENGKTFTENALIKAQTLTDLYKIPVLADDSGIVVDYLNGEPGIYSARYAGDHDDEANKKKLLHNLEGVPFEKRTAHFHCSLVITSPVKDPLIAEGNVEGYIVEEERGKGGFGYDPLFFYPPFDKTFGETTADEKNAVSHRANAIKDLLTKFDEWWEE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NBEB01000052
EMBL· GenBank· DDBJ
OQQ83495.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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