A0A1V9BU81 · A0A1V9BU81_9BACI

Function

function

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.

Pathway

Protein modification; protein lipoylation via endogenous pathway; protein N6-(lipoyl)lysine from octanoyl-[acyl-carrier-protein].

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site40[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site45[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site51[4Fe-4S] cluster 1 (UniProtKB | ChEBI)
Binding site67[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site71[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site74[4Fe-4S] cluster 2 (UniProtKB | ChEBI); 4Fe-4S-S-AdoMet
Binding site280[4Fe-4S] cluster 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionlipoate synthase activity
Molecular Functionmetal ion binding
Biological Processprotein lipoylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Lipoyl synthase
  • EC number
  • Alternative names
    • Lip-syn
      (LS
      )
    • Lipoate synthase
    • Lipoic acid synthase
    • Sulfur insertion protein LipA

Gene names

    • Name
      lipA
    • ORF names
      B9L19_03110

Organism names

  • Taxonomic identifier
  • Strain
    • BGSC 93A1
  • Taxonomic lineage
    Bacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Geobacillus > Geobacillus thermoleovorans group

Accessions

  • Primary accession
    A0A1V9BU81

Proteomes

Subcellular Location

Keywords

Family & Domains

Sequence similarities

Belongs to the radical SAM superfamily. Lipoyl synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    298
  • Mass (Da)
    34,056
  • Last updated
    2017-06-07 v1
  • Checksum
    5618D29340DB394C
MATKEEHVRKPDWLKIKLNTNENYIGLKKLMRENRLHTVCEEAKCPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDWQEPERVAESVRIMNLKHVVVTAVARDDLKDGGAAVFAETVRAIRRKNPFTTIEVLPSDMGGVYENLKILMDARPDILNHNIETVRRLTPRVRARATYERSLEFLRRAKELQPDIPTKSSIMVGLGETKEEIIEAMDDLRANHVDILTIGQYLQPTKKHLKVVKYYHPDEFQELKEIALSKGFSHCEAGPLVRSSYHADEQVSEAAKARQLKA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
NEWK01000001
EMBL· GenBank· DDBJ
OXB89093.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp