A0A1V6IPL3 · A0A1V6IPL3_9EURY
- ProteinATP phosphoribosyltransferase
- GenehisG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids289 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
Catalytic activity
- 1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP
Cofactor
Activity regulation
Feedback inhibited by histidine.
Pathway
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | ATP phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Biological Process | L-histidine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP phosphoribosyltransferase
- EC number
- Short namesATP-PRT ; ATP-PRTase
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota
Accessions
- Primary accessionA0A1V6IPL3
Proteomes
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 49-209 | ATP phosphoribosyltransferase catalytic | |||
Domain | 214-286 | Histidine biosynthesis HisG C-terminal | |||
Sequence similarities
Belongs to the ATP phosphoribosyltransferase family. Long subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length289
- Mass (Da)31,885
- Last updated2017-06-07 v1
- Checksum3BC708CD284353D7
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
MWEX01000006 EMBL· GenBank· DDBJ | OQC52355.1 EMBL· GenBank· DDBJ | Genomic DNA |