A0A1V6FFG3 · A0A1V6FFG3_9FIRM

Function

function

Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.
Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site46Part of a proton relay during catalysis
Binding site47pyruvate (UniProtKB | ChEBI)
Site109Part of a proton relay during catalysis
Active site135Proton donor/acceptor
Active site163Schiff-base intermediate with substrate
Binding site205pyruvate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Function4-hydroxy-tetrahydrodipicolinate synthase activity
Biological Processdiaminopimelate biosynthetic process
Biological Processlysine biosynthetic process via diaminopimelate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxy-tetrahydrodipicolinate synthase
  • EC number
  • Short names
    HTPA synthase

Gene names

    • Name
      dapA
    • ORF names
      BWX72_01955

Organism names

Accessions

  • Primary accession
    A0A1V6FFG3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homotetramer; dimer of dimers.

Family & Domains

Sequence similarities

Belongs to the DapA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    291
  • Mass (Da)
    31,380
  • Last updated
    2017-06-07 v1
  • Checksum
    C8C568A40F07110C
MAYIFQGVGTALITPMLDNKIDYISLEKLVKTQLDSGIACLVANGTTGEPSTISDEEKIKIASVVIEIVNKKIPVIVGAGSNSTEHAIRQAIDAKSVGADGLLCVTPYYNKCTQQGLIEHFKSIADQVDLPIIMYNVPSRTGLNMLPETVAKLAGYKGICAIKEASGNISQIMELACISGNDFFLYSGDDGLTYPILTLGGAGVISVASNVIPKYMHEMVDSYFTGNVEKSRNMQLRILPFIKALFLEVNPIPVKCAAKLLGICSDEVRLPLTKCTCESILEKELKNLGLL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MWEH01000192
EMBL· GenBank· DDBJ
OQC12373.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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