A0A1V6FAM2 · A0A1V6FAM2_9BACT

Function

function

Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

1767100200300400500600700
Type
IDPosition(s)Description
Binding site322-329ATP (UniProtKB | ChEBI)
Binding site544Zn2+ (UniProtKB | ChEBI); catalytic
Active site545
Binding site548Zn2+ (UniProtKB | ChEBI); catalytic
Binding site619Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionmetalloendopeptidase activity
Molecular Functionzinc ion binding
Biological Processprotein catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent zinc metalloprotease FtsH
  • EC number

Gene names

    • Name
      ftsH
    • ORF names
      BWX75_00313

Organism names

Accessions

  • Primary accession
    A0A1V6FAM2

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein
Membrane

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane83-103Helical
Transmembrane139-156Helical
Transmembrane229-250Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_501072425220-767ATP-dependent zinc metalloprotease FtsH

Interaction

Subunit

Homohexamer.

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region109-131Disordered
Domain314-453AAA+ ATPase

Sequence similarities

Belongs to the AAA ATPase family.
In the C-terminal section; belongs to the peptidase M41 family.
In the central section; belongs to the AAA ATPase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    767
  • Mass (Da)
    84,977
  • Last updated
    2017-06-07 v1
  • MD5 Checksum
    3BF0B8013691301FD21E9CFE10CF66B1
MKRLLIFCLALLWLQLILAQSNTTSPAFTVGDSLVQEQPQAGLADNPNEQSPAKDKIDSLTSPLFHQEQGAIGSALREFGSMIRWFILALLVISVISVLRIIITKRLKAPGPDQAPDKSKNPPNMPPGMKMPKKAPGSYTLIIIMLLLALLFFFTWRNSRQQVKEKDYTTFIAQVERGEVTTTEFTQRDILYKDVKGNQFHTVMPFDDPDLIDKLVAGNVTIITRKPSVWGGILSYIFPFILLIGLWFFFLRGMGNQNSKAFSFGKSRARLHEGSKSQVTFKDVAGVDEAKEELQEIVEFLKDPKKFQRLGGRIPRGVLLVGRPGTGKTLLAKAVSGEAGVPFFSISGSDFVEMFVGVGAARVRDLFEQAKKSAPCITFIDEIDAVGRHRGSGLGGGHDEREQTLNQLLVEMDGFEPNEAVIIIAATNRPDILDPALLRPGRFDRQVTVDLPDIKGRTEILKVHSSKVPLAKDVNLEIIARGTPGFSGADLANIVNEAALIAARHGKQRIGMGDFEEAKDKLILGKEKKSRVIPEEDKKLTAYHEVGHVLTSVFQEKTDPVHKVSIIPRGFTGGATHFLQTDKTGYSRSYLEQIMAELLGGRAAEEIVFNELTTGAGNDLERVTEIAKKMVCTWGMSDKIGPMTIGKNASEVYLGKELVGRDVHSNETIGMVDSEIRAFIAKAYQTALDILKKHESLLHEMAGILIEKETLGTDRIFKIILDRVDEEDRALIESKYAKAKEMRFEHSEKLTKEKAALEAEKAEEAKQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MWEE01000004
EMBL· GenBank· DDBJ
OQC10684.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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