A0A1V4X4Z3 · A0A1V4X4Z3_9BACT

Function

function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site1-8ATP (UniProtKB | ChEBI)
Active site8Proton donor
Binding site32(R)-pantoate (UniProtKB | ChEBI)
Binding site32beta-alanine (UniProtKB | ChEBI)
Binding site118-121ATP (UniProtKB | ChEBI)
Binding site124(R)-pantoate (UniProtKB | ChEBI)
Binding site147ATP (UniProtKB | ChEBI)
Binding site155-158ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionpantoate-beta-alanine ligase activity
Biological Processpantothenate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pantothenate synthetase
  • EC number
  • Short names
    PS
  • Alternative names
    • Pantoate--beta-alanine ligase
    • Pantoate-activating enzyme

Gene names

    • Name
      panC
    • ORF names
      A4E67_02276

Organism names

Accessions

  • Primary accession
    A0A1V4X4Z3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the pantothenate synthetase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    256
  • Mass (Da)
    28,638
  • Last updated
    2017-06-07 v1
  • Checksum
    299579B941661C0B
MGYLHRGHLSLMEEGRKRGDCLVTSIYVNPTQFGPKEDLAKYPRDFDMDYRLCQGVGVDVIFYPSDAEMYPEHYQTYVDLDGVTQNLCGLSRPGHFRGVATICAKLFNLVKPHVAVFGKKDFQQLVVIKRMVEDLNMDLEIVGLDTVREPDGLAMSSRNTYLKPEERESALSLSRGLKMAQGMYARGERDAAVILDAVRRFIAGHPHAAIDYVKICDTTTMKDVERLDGDCVMALAVRVGAARLIDNSVFGEPLNV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MVQS01000389
EMBL· GenBank· DDBJ
OPY04668.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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