A0A1V4U0M5 · A0A1V4U0M5_9EURY

Function

function

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

132750100150200250300
TypeIDPosition(s)Description
Binding site240Mn2+ (UniProtKB | ChEBI)
Binding site252Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological Processdefense response to virus
Biological Processmaintenance of CRISPR repeat elements

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CRISPR-associated endonuclease Cas1
  • EC number

Gene names

    • Name
      cas1-2_2
    • Synonyms
      cas1
    • ORF names
      A4E36_02029

Organism names

Accessions

  • Primary accession
    A0A1V4U0M5

Proteomes

Interaction

Subunit

Homodimer, forms a heterotetramer with a Cas2 homodimer.

Family & Domains

Sequence similarities

Belongs to the CRISPR-associated endonuclease Cas1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    327
  • Mass (Da)
    36,450
  • Last updated
    2017-06-07 v1
  • Checksum
    B9BE3AC86862892A
MSISETFPSFKKNMEWSVIEPVPWYLVSGFGAHLKATPRTLTVQKNGHTEELPLSRVRHLLVMGGHHIHTSVVARLLASGSCISFFEADGEPLGIAKPFGFRYDEVVREAQAKAYSHSFALAVAKGSIHSRIQALVGLQEARDEPLFYEGELEILEKSYAELEFLVRVEELRRVHRLASDMYYEILARTIPQETGFRRRTARPHVDVVNTMLSFGYGLLFGNACVAAIGAHLDPDLGFLHKGKGGLVYDIIDPFKPAMVDGMVSAIAREGIPEEEYECGPSRCILSDDLLVVLTKALHETIRQEVIDEQVMALQGALIKKNDYLVIT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MVQC01000130
EMBL· GenBank· DDBJ
OPX66386.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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