A0A1V4U0G3 · A0A1V4U0G3_9EURY
- Protein6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
- GenemptE
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids204 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP).
Catalytic activity
- 6-hydroxymethyl-7,8-dihydropterin + ATP = (7,8-dihydropterin-6-yl)methyl diphosphate + AMP + H+
Cofactor
Pathway
Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity | |
Molecular Function | ATP binding | |
Molecular Function | kinase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | thiamine diphosphokinase activity | |
Biological Process | phosphorylation | |
Biological Process | tetrahydromethanopterin biosynthetic process | |
Biological Process | thiamine diphosphate biosynthetic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
- EC number
- Short namesHPPK
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Euryarchaeota > Stenosarchaea group > Methanomicrobia > Methanomicrobiales > Methanoregulaceae
Accessions
- Primary accessionA0A1V4U0G3
Proteomes
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 34-182 | 6-hydroxymethylpterin diphosphokinase MptE-like | ||||
Sequence: LLERDDLDLLEETCRGHDVCVCGNAPCLVKEIPLVRGTVLAADAASLVLLSHGIRPDVIFTDLDGATDEFLDMNREGTIVVVHAHGDNIPLVRYWVPRFPGPLVGTTQSRPLPHVHNFGGFTDGDRAVFAAHSLGAAGITLLGFDLEDT |
Sequence similarities
Belongs to the archaeal 6-HMPDK family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length204
- Mass (Da)22,658
- Last updated2017-06-07 v1
- Checksum1D57A2980BDF752C