A0A1V4T9X5 · A0A1V4T9X5_9EURY

Function

function

Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionDNA binding
Molecular FunctionDNA-directed DNA polymerase activity
Molecular Functionphosphoric ester hydrolase activity
Molecular Functionzinc ion binding
Biological ProcessDNA repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA polymerase beta
  • EC number
  • Alternative names
    • 5'-deoxyribose-phosphate lyase
    • AP lyase

Gene names

    • ORF names
      A4E25_02293

Organism names

  • Taxonomic identifier
  • Strain
    • PtaB.Bin024
  • Taxonomic lineage
    Archaea > Euryarchaeota > Methanomada group > Methanobacteria > Methanobacteriales > Methanobacteriaceae > Methanobacterium

Accessions

  • Primary accession
    A0A1V4T9X5

Proteomes

Subcellular Location

PTM/Processing

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-312DNA-directed DNA polymerase X
Domain50-69Helix-hairpin-helix DNA-binding motif class 1
Domain90-109Helix-hairpin-helix DNA-binding motif class 1
Domain125-144Helix-hairpin-helix DNA-binding motif class 1
Domain336-414Polymerase/histidinol phosphatase N-terminal

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    566
  • Mass (Da)
    63,884
  • Last updated
    2017-06-07 v1
  • Checksum
    8119DAD80ECEFE5B
MQNKKVASILSRVADYLEMDGVNFRTKAYRRAAHTIETLSVDIADISGEGQLENLPGIGKHIALKIQEILNTGKLQYLEDLKDEYPLDLDALMSVEGLGPKKIQLLFHELGIMTLDDLEREGKHHHIRRLKGMGAKTEAKILQNLEFARKSTGRELLGEVLPLAQEIKRRISALEGIQQVEIAGSIRRRKETVGDIDILTVTDHPEEVMDFFTHMDVVDEIIVKGHSKSTVRLYNGMDADIRAFKDEDFGSALLYFTGSRELNIHLRKIAISNKMKLNEYGVFKDDECLANKTEKDVFKVLGLDYIPPELRENTGEVEAAQEGKLPNLVDYNDIKGDLHLHTNWSDGKSSINQMVSEAIDLGYEYLAITDHTSLPVARGMDDKRLKEQMSKIDIINSQIDDITVLKGAEVNLDSQGNLDISEDVLEELDLVIAAVHYDFHQEPEKMNKRILNALENEYVDILAHPTGRKLKERQAYELDFEQLFQKATETGTILEVNSSPKRLDLKDIHVKMALEHGCQLVVNTDAHHVHDLGNIGLGVATARRGWAEEKDIINTLPLKKLLKLLN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MVPY01000099
EMBL· GenBank· DDBJ
OPX57393.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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