A0A1V4I2Q5 · A0A1V4I2Q5_NITVU
- ProteinGlycerol kinase
- GeneglpK
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids500 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.
Catalytic activity
- ATP + glycerol = ADP + H+ + sn-glycerol 3-phosphate
Activity regulation
Inhibited by fructose 1,6-bisphosphate (FBP).
Pathway
Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 12 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 12 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 12 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 13 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 14 | ATP (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 16 | ADP (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 82 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 82 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Binding site | 83 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 83 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 134 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 134 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 243 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 243 | sn-glycerol 3-phosphate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 244 | glycerol (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 265 | ADP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 265 | ATP (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 308 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 308 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 312 | ATP (UniProtKB | ChEBI) | ||||
Sequence: Q | ||||||
Binding site | 412 | ADP (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 412 | ATP (UniProtKB | ChEBI) | ||||
Sequence: G |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | glycerol kinase activity | |
Biological Process | glycerol catabolic process | |
Biological Process | glycerol-3-phosphate metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGlycerol kinase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Nitrobacteraceae > Nitrobacter
Accessions
- Primary accessionA0A1V4I2Q5
Proteomes
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-250 | Carbohydrate kinase FGGY N-terminal | ||||
Sequence: ILAIDQGTTSSRAIVFRADISIAAIAQQEFPQHFPASGWVEHEPEDIWTSTVATCRQAMKKAGVTPKDIAAIGITNQRETTVVWDRATGKAVHRAIVWQDRRTADICARLKAEGHEPAISAKTGLIIDPYFSGTKVAWILDSVPGARARAMRGELMFGTVDCYLLWRLTGGKVHATDATNASRTLLFNIHTGQWDDELLDMLQVPRAMLPEVKDSSLHFGDSAPELFGAPISIRGIAGDQQAAVVG | ||||||
Domain | 261-451 | Carbohydrate kinase FGGY C-terminal | ||||
Sequence: STYGTGCFALLNTGTTPVASNNKLLTTIAYQLNGQRTYALEGSIFVAGSAVQWLRDGLGLIKQASDTGPLAEQSDPTQSVYLVPAFVGMGAPYWKPNVRGALFGLTRNTGPAELAHAALESVCYQTFDLWDAMRADWPGADAAHTVLRVDGGMTASDWTMQRLADLLEAPVDRPVIQETTALGAAYLAGLS |
Sequence similarities
Belongs to the FGGY kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length500
- Mass (Da)54,027
- Last updated2017-06-07 v1
- Checksum39E7C07744C8FE08