A0A1V1TNA7 · A0A1V1TNA7_9PEZI

  • Protein
    ATP-dependent DNA helicase II subunit 2
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentchromosome, telomeric region
Cellular ComponentKu70:Ku80 complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functiondamaged DNA binding
Molecular Functionhelicase activity
Molecular Functiontelomeric DNA binding
Biological ProcessDNA recombination
Biological Processdouble-strand break repair via nonhomologous end joining
Biological Processtelomere maintenance

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent DNA helicase II subunit 2
  • EC number

Gene names

    • ORF names
      ANO14919_117580

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • No.14919
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Xylariomycetidae > Xylariales

Accessions

  • Primary accession
    A0A1V1TNA7

Proteomes

Subcellular Location

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain307-444Ku
Compositional bias553-575Basic and acidic residues
Region553-578Disordered

Sequence similarities

Belongs to the ku80 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    719
  • Mass (Da)
    80,755
  • Last updated
    2017-06-07 v1
  • Checksum
    7689970FFCE428E6
MADKEATVYILDLGSSMADCHNGRTESDLDWSMRYVWDKISTTVAASRKTWNVGVVGVRTDETDNPLGGQEDGCEGYEHISVLQELGPMTMNNLTILRDRVKTSDTQTGDCISAIVLAIEMIEKLTKKLKYSRRIILVTAGEAPIDSSDIGDISEKMKRSGIQLTVLGVDFDDVEFGFTEEDKPSIKEQNEEILRDLVDKCDGLYGTMAEAISELETPRVKSIKPYKTYDGILTLGNPDVHEDAMSIYVERYFKTHKATVPPASRVAMKTEPTNSDEMQGVEPAPSFSAVKDTRTYKVNDPDAPGGKRDVDYSELAKGYEYGRTAVHISESDYNITKIETTKSFSIVGFIYQEKYEPFLNMGETCMTVAQKSNDAAALKLSSLIHSLHELESYAVARIVTKDGKEPALILLAPNIEPDFECLYDVPLPFAEDVRNYPFPPLGRVVTVQGKTITENHRNLPSQELQEAMDDYVDAMDISSWEKDDEGNRTMEYAAVEDLFSPPLHRINQVVRHRATYPNQPVPPTPSILLKYANPPEDLVAKAKSDLEDLIDKASVKKVPPKAKGKRDKGDKPKPISGLDIDALLKRPENRRAKISSNKAIPEFKQKVELAEDQADIEDAMKQMGAIIRNMVTESFGDQEYDRIIEHIGAMRETAIDYEYPDLFTSFMKDFKTRLLSGEFNGDRRELWFKIKSIRLGLIDNNVSEHSKTTPEEAAKFFKK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias553-575Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BDMC01000048
EMBL· GenBank· DDBJ
GAW22222.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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