A0A1V0QSH7 · FPPS2_CANSA

Function

function

Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Sesquiterpene biosynthesis.
Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site46isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site49isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site85isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site92Mg2+ 1 (UniProtKB | ChEBI)
Binding site92Mg2+ 2 (UniProtKB | ChEBI)
Binding site96Mg2+ 1 (UniProtKB | ChEBI)
Binding site96Mg2+ 2 (UniProtKB | ChEBI)
Binding site101dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site102isopentenyl diphosphate (UniProtKB | ChEBI)
Binding site189dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site190dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site228dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site245dimethylallyl diphosphate (UniProtKB | ChEBI)
Binding site254dimethylallyl diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functiondimethylallyltranstransferase activity
Molecular Functiongeranyltranstransferase activity
Molecular Functionmetal ion binding
Biological Processcholesterol biosynthetic process
Biological Processfarnesyl diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Farnesyl pyrophosphate synthase 2
  • EC number
  • Short names
    CsFPPS2
    ; FPP synthase 2
  • Alternative names
    • (2E,6E)-farnesyl diphosphate synthase
    • Dimethylallyltranstransferase
      (EC:2.5.1.1
      ) . EC:2.5.1.1 (UniProtKB | ENZYME | Rhea)
    • Farnesyl diphosphate synthase
    • Geranyltranstransferase

Gene names

    • Name
      FPPS2
    • ORF names
      F8388_008233
      , G4B88_016657

Organism names

  • Taxonomic identifier
  • Strains
    • cv. Finola
    • cv. Purple Kush TPS13
    • cv. Jamaican Lion 4
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Rosales > Cannabaceae > Cannabis

Accessions

  • Primary accession
    A0A1V0QSH7
  • Secondary accessions
    • A0A7J6EXE4
    • A0A7J6H7T3
    • A0A803QBT5

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004608931-341Farnesyl pyrophosphate synthase 2

Expression

Tissue specificity

Mainly expressed in trichomes, roots and flowers, and, to a lower extent, in leaves and stems.

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the FPP/GGPP synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    341
  • Mass (Da)
    39,397
  • Last updated
    2024-10-02 v2
  • Checksum
    6DEBB557E709ADF7
MDLKSKFMEVYYKLKSELLNDPAFEFTDDSRQWVEQMLDYNVPGGKLNRGLSVIDSYQILKGGKELTEEEIFLTSALGWCIEWLQAYFLVLDDIMDNSVTRRGQPCWFRVPKVGLIAANDGILLRNHIPRILKKHFKGKSYYVDLLDLFNEVEFQTASGQMIDLITTIEGEKDLSKYSIPLHHRIVQYKTAYYSFYLPVACALVMAGENLDNHVDVKNILIEMGTYFQVQDDYLDCFGHPDVIGKIGTDIEDFKCSWLVVKALEIVTDEQKKLLFEHYGKADEASVKKVKELYKTLDLEGVFADYESTSYQKLNKSIEAHPKKEVQAVLKSFLAKIYKRQK

Sequence caution

The sequence KAF4362349.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence KAF4391347.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict12in Ref. 1; ARE72275
Sequence conflict20in Ref. 1; ARE72275
Sequence conflict35in Ref. 1; ARE72275

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY014580
EMBL· GenBank· DDBJ
ARE72275.1
EMBL· GenBank· DDBJ
mRNA
JAATIP010000185
EMBL· GenBank· DDBJ
KAF4362349.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
JAATIQ010000060
EMBL· GenBank· DDBJ
KAF4391347.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
UZAU01000678
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

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