A0A1V0QSH7 · FPPS2_CANSA
- ProteinFarnesyl pyrophosphate synthase 2
- GeneFPPS2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids341 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Catalytic activity
- isopentenyl diphosphate + dimethylallyl diphosphate = (2E)-geranyl diphosphate + diphosphateThis reaction proceeds in the forward direction.
Cofactor
Note: Binds 2 Mg2+ ions per subunit.
Pathway
Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Sesquiterpene biosynthesis.
Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 46 | isopentenyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 49 | isopentenyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 85 | isopentenyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 92 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 92 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 96 | Mg2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 96 | Mg2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 101 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 102 | isopentenyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 189 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 190 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 228 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 245 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
Binding site | 254 | dimethylallyl diphosphate (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | dimethylallyltranstransferase activity | |
Molecular Function | geranyltranstransferase activity | |
Molecular Function | metal ion binding | |
Biological Process | cholesterol biosynthetic process | |
Biological Process | farnesyl diphosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFarnesyl pyrophosphate synthase 2
- EC number
- Short namesCsFPPS2 ; FPP synthase 2
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Rosales > Cannabaceae > Cannabis
Accessions
- Primary accessionA0A1V0QSH7
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000460893 | 1-341 | Farnesyl pyrophosphate synthase 2 | ||
Expression
Tissue specificity
Mainly expressed in trichomes, roots and flowers, and, to a lower extent, in leaves and stems.
Structure
Sequence
- Sequence statusComplete
- Length341
- Mass (Da)39,397
- Last updated2024-10-02 v2
- Checksum6DEBB557E709ADF7
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 12 | in Ref. 1; ARE72275 | |||
Sequence conflict | 20 | in Ref. 1; ARE72275 | |||
Sequence conflict | 35 | in Ref. 1; ARE72275 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KY014580 EMBL· GenBank· DDBJ | ARE72275.1 EMBL· GenBank· DDBJ | mRNA | ||
JAATIP010000185 EMBL· GenBank· DDBJ | KAF4362349.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
JAATIQ010000060 EMBL· GenBank· DDBJ | KAF4391347.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
UZAU01000678 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |