A0A1V0N4G4 · A0A1V0N4G4_9ARCH

  • Protein
    Carbamoyl phosphate synthase small chain
  • Gene
    carA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Small subunit of the glutamine-dependent carbamoyl phosphate synthetase (CPSase). CPSase catalyzes the formation of carbamoyl phosphate from the ammonia moiety of glutamine, carbonate, and phosphate donated by ATP, constituting the first step of 2 biosynthetic pathways, one leading to arginine and/or urea and the other to pyrimidine nucleotides. The small subunit (glutamine amidotransferase) binds and cleaves glutamine to supply the large subunit with the substrate ammonia.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.
Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site45L-glutamine (UniProtKB | ChEBI)
Binding site213L-glutamine (UniProtKB | ChEBI)
Binding site215L-glutamine (UniProtKB | ChEBI)
Active site242Nucleophile
Binding site243L-glutamine (UniProtKB | ChEBI)
Binding site246L-glutamine (UniProtKB | ChEBI)
Binding site282L-glutamine (UniProtKB | ChEBI)
Binding site284L-glutamine (UniProtKB | ChEBI)
Binding site285L-glutamine (UniProtKB | ChEBI)
Active site325
Active site327

GO annotations

AspectTerm
Cellular Componentcarbamoyl-phosphate synthase complex
Molecular FunctionATP binding
Molecular Functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Molecular Functionglutaminase activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process
Biological Processarginine biosynthetic process
Biological Processglutamine metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Carbamoyl phosphate synthase small chain
  • EC number
  • Alternative names
    • Carbamoyl phosphate synthetase glutamine chain

Gene names

    • Name
      carA
    • ORF names
      FAD_1154

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Y
  • Taxonomic lineage
    Archaea > Candidatus Thermoplasmatota > Thermoplasmata > Thermoplasmatales > Ferroplasmaceae > Ferroplasma

Accessions

  • Primary accession
    A0A1V0N4G4

Proteomes

Subcellular Location

Interaction

Subunit

Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. Tetramer of heterodimers (alpha,beta)4.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain1-131Carbamoyl-phosphate synthase small subunit N-terminal
Region1-164CPSase

Sequence similarities

Belongs to the CarA family.
Belongs to the CarB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    350
  • Mass (Da)
    39,142
  • Last updated
    2017-06-07 v1
  • Checksum
    0C681C7B3A304E90
MKRYLLLEDGTTYEGTGYGYEGETNGEIVFTTSMSGYLETITDPSYAGEILIFAFPEIANYPLNLEHMESSKVQVAGIITKDAHAIFSGGESGTGFNEFLKQNMVPAIDGIDTRSLVEKIRESGAIKGYIRNKNEFPDKFEDTMDLDLVSRVSIKKYKYYNSGHKKEILFIDVGTKNSLIKRLSETASLHIVPYNYDFFNIKFHYDAIFIPNGPGNPDHSSLEPLRAFIREKSSSMPVMGVCLGNQLIALSMGGKTEKMKYGHRGINHAVLIGNRVYITSHNHGYAVNGDSLKGTCMEICGTDINDGTVEMIKHRELPVFSVQFHPEAYPGPYDSTWFFNDIKTTLGEKI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015363
EMBL· GenBank· DDBJ
ARD85030.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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