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A0A1V0N1J6 · A0A1V0N1J6_9ARCH

  • Protein
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • Gene
    nnrD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
K+ (UniProtKB | Rhea| CHEBI:29103 )

Note: Binds 1 potassium ion per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site232(6S)-NADPHX (UniProtKB | ChEBI)
Binding site291(6S)-NADPHX (UniProtKB | ChEBI)
Binding site338(6S)-NADPHX (UniProtKB | ChEBI)
Binding site397AMP (UniProtKB | ChEBI)
Binding site398(6S)-NADPHX (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionADP-dependent NAD(P)H-hydrate dehydratase activity
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmetal ion binding
Molecular FunctionNADHX epimerase activity
Molecular FunctionNADPHX epimerase activity
Biological Processmetabolite repair
Biological Processnicotinamide nucleotide metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ADP-dependent (S)-NAD(P)H-hydrate dehydratase
  • EC number
  • Alternative names
    • ADP-dependent NAD(P)HX dehydratase

Gene names

    • Name
      nnrD
    • ORF names
      FAD_0060
      , HLB00_07405

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • Berkeley
    • Y
    • DSM 28986
  • Taxonomic lineage
    Archaea > Candidatus Thermoplasmatota > Thermoplasmata > Thermoplasmatales > Ferroplasmaceae > Ferroplasma

Accessions

  • Primary accession
    A0A1V0N1J6

Proteomes

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-196YjeF N-terminal
Domain198-456YjeF C-terminal

Sequence similarities

Belongs to the NnrD/CARKD family.
In the C-terminal section; belongs to the NnrD/CARKD family.
In the N-terminal section; belongs to the NnrE/AIBP family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    457
  • Mass (Da)
    49,523
  • Last updated
    2017-06-07 v1
  • MD5 Checksum
    9BED5824F159EA23E630F5A55C06D673
MDYLDEKSMDINYASTYGNTYKLMKQAGKSISDFVERTIQPGKSIAIICGTGNNAGDGICCGEYLLEKYNVSVLLIKDVKGLKTQETRRAINDYNGAYYPLSSLDEVISRSDIIIDAIFGVGINGDPRKPYSEVIQNINNSGKTIISVDVPSGFPTNIQVKPDYTVTFTDIKSGMNSENSGKIIVSDIGIPEQIKSTVGPGDMVYMPISPSESHKGMNGIVGILAGWEFPGAAVMSSLSAYNVGPDLVKVFTNEVNRPIIMSYNPGIMFYPVNGKNFPDITGLNSMLIGPGMGRSKEAEDLIKYAIKNYNGQLILDADALKLITPPEVKGRNAIITPHSMEFKAFTGLEPTEENAVETAKKYGLIILLKGSKDIITDGVNIRYSYGGNSRMTMGGTGDVLAGIVAGIASRKVSPLRSASLGSFINKKCGDIAFEKFGSYYGIMDMIDNIKIIMHNKF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP015363
EMBL· GenBank· DDBJ
ARD83993.1
EMBL· GenBank· DDBJ
Genomic DNA
JABGBP010000270
EMBL· GenBank· DDBJ
NOL60653.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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