A0A1U9X967 · A0A1U9X967_HUMAN

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Features

Showing features for binding site.

119992004006008001,0001,2001,4001,6001,800
TypeIDPosition(s)Description
Binding site451Ca2+ 1 (UniProtKB | ChEBI)
Binding site454Ca2+ 1 (UniProtKB | ChEBI)
Binding site471Ca2+ 2 (UniProtKB | ChEBI)
Binding site474Ca2+ 2 (UniProtKB | ChEBI)
Binding site488Ca2+ 2 (UniProtKB | ChEBI)
Binding site510Ca2+ 3 (UniProtKB | ChEBI)
Binding site512Ca2+ 3 (UniProtKB | ChEBI)
Binding site526Ca2+ 3 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi membrane
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functioncalcium ion binding
Molecular Functionsignaling receptor activity
Biological Processcell differentiation
Biological Processdevelopmental growth
Biological ProcessNotch signaling pathway
Biological Processregulation of developmental process
Biological Processregulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • NOTCH4

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1U9X967

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane
; Single-pass type I membrane protein
Nucleus

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_501100361320-1999
Disulfide bond49↔58
Disulfide bond101↔110
Disulfide bond141↔150
Disulfide bond178↔187
Disulfide bond218↔227
Disulfide bond260↔269
Disulfide bond298↔307
Disulfide bond339↔348
Disulfide bond377↔386
Disulfide bond397↔414
Disulfide bond416↔425
Disulfide bond432↔448
Disulfide bond442↔457
Disulfide bond459↔468
Disulfide bond475↔486
Disulfide bond480↔495
Disulfide bond497↔506
Disulfide bond513↔524
Disulfide bond518↔533
Disulfide bond535↔544
Disulfide bond573↔582
Disulfide bond611↔620
Disulfide bond713↔722
Disulfide bond751↔760
Disulfide bond789↔798
Disulfide bond828↔837
Disulfide bond866↔875
Disulfide bond914↔923
Disulfide bond952↔961
Disulfide bond990↔999
Disulfide bond1011↔1028
Disulfide bond1030↔1039
Disulfide bond1071↔1080
Disulfide bond1112↔1121
Disulfide bond1157↔1166

Keywords

Proteomic databases

Family & Domains

Features

Showing features for domain, region, repeat.

TypeIDPosition(s)Description
Domain20-59EGF-like
Domain60-111EGF-like
Domain114-151EGF-like
Domain152-188EGF-like
Domain190-228EGF-like
Domain230-270EGF-like
Domain272-308EGF-like
Domain310-349EGF-like
Domain351-387EGF-like
Domain388-426EGF-like
Domain428-469EGF-like
Domain471-507EGF-like
Domain509-545EGF-like
Domain547-583EGF-like
Domain585-621EGF-like
Domain687-723EGF-like
Domain725-761EGF-like
Domain763-799EGF-like
Domain802-838EGF-like
Domain840-876EGF-like
Domain889-924EGF-like
Domain926-962EGF-like
Domain964-1000EGF-like
Domain1002-1040EGF-like
Domain1042-1081EGF-like
Domain1083-1122EGF-like
Domain1126-1167EGF-like
Domain1166-1209LNR
Domain1210-1246LNR
Domain1247-1290LNR
Region1336-1367Disordered
Region1481-1504Disordered
Repeat1629-1661ANK
Repeat1662-1684ANK
Repeat1696-1728ANK
Repeat1729-1761ANK
Repeat1762-1794ANK
Region1896-1923Disordered
Region1964-1999Disordered

Sequence similarities

Belongs to the NOTCH family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,999
  • Mass (Da)
    209,110
  • Last updated
    2017-08-30 v2
  • Checksum
    2DB4401892BB557B
MQPPSLLLLLLLCVSVVRPRGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAQLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPSLALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGAPAEEKLGGTRDPTYQERAAPQTQPLGKETDSLSAGFVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHAGTAPPANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLWSLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGRVSTDDWPCDWVALGACGSASNIPIPPPCLTPSPERGSPQLDCGPPALQEMPINQGGEGKK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY500864
EMBL· GenBank· DDBJ
AQY77332.2
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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