A0A1U9X967 · A0A1U9X967_HUMAN
- ProteinNOTCH4
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1999 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 451 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 454 | Ca2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 471 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 474 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 488 | Ca2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 510 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: T | ||||||
Binding site | 512 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 526 | Ca2+ 3 (UniProtKB | ChEBI) | ||||
Sequence: D |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Golgi membrane | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane | |
Molecular Function | calcium ion binding | |
Molecular Function | signaling receptor activity | |
Biological Process | cell differentiation | |
Biological Process | developmental growth | |
Biological Process | Notch signaling pathway | |
Biological Process | regulation of developmental process | |
Biological Process | regulation of DNA-templated transcription |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Submitted names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A1U9X967
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Membrane ; Single-pass type I membrane protein
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MQPPSLLLLLLLCVSVVRP | ||||||
Chain | PRO_5011003613 | 20-1999 | ||||
Sequence: RGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQAQLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPLCAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPACTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWGPSLALLVVLSPPALDQQLFALARVLSLTLRVGLWVRKDRDGRDMVYPYPGAPAEEKLGGTRDPTYQERAAPQTQPLGKETDSLSAGFVVVMGVDLSRCGPDHPASRCPWDPGLLLRFLAAMAAVGALEPLLPGPLLAVHPHAGTAPPANQLPWPVLCSPVAGVILLALGALLVLQLIRRRRREHGALWLPPGFTRRPRTQSAPHRRRPPLGEDSIGLKALKPKAEVDEDGVVMCSGPEEGEEVGQAEETGPPSTCQLWSLSGGCGALPQAAMLTPPQESEMEAPDLDTRGPDGVTPLMSAVCCGEVQSGTFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHAAVAADAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELRDQAGLAPADVAHQRNHWDLLTLLEGAGPPEARHKATPGREAGPFPRARTVSVSVPPHGGGALPRCRTLSAGAGPRGGGACLQARTWSVDLAARGGGAYSHCRSLSGVGAGGGPTPRGRRFSAGMRGPRPNPAIMRGRYGVAAGRGGRVSTDDWPCDWVALGACGSASNIPIPPPCLTPSPERGSPQLDCGPPALQEMPINQGGEGKK | ||||||
Disulfide bond | 49↔58 | |||||
Sequence: CAPGFLGETC | ||||||
Disulfide bond | 101↔110 | |||||
Sequence: CLPGFTGERC | ||||||
Disulfide bond | 141↔150 | |||||
Sequence: CMPGWTGEQC | ||||||
Disulfide bond | 178↔187 | |||||
Sequence: CPPGFEGHAC | ||||||
Disulfide bond | 218↔227 | |||||
Sequence: CPVGQEGPRC | ||||||
Disulfide bond | 260↔269 | |||||
Sequence: CPPGFIGPDC | ||||||
Disulfide bond | 298↔307 | |||||
Sequence: CPETWTGWDC | ||||||
Disulfide bond | 339↔348 | |||||
Sequence: CVSGWGGTSC | ||||||
Disulfide bond | 377↔386 | |||||
Sequence: CPPGRTGLLC | ||||||
Disulfide bond | 397↔414 | |||||
Sequence: CHGDAQCSTNPLTGSTLC | ||||||
Disulfide bond | 416↔425 | |||||
Sequence: CQPGYSGPTC | ||||||
Disulfide bond | 432↔448 | |||||
Sequence: CLMAQQGPSPCEHGGSC | ||||||
Disulfide bond | 442↔457 | |||||
Sequence: CEHGGSCLNTPGSFNC | ||||||
Disulfide bond | 459↔468 | |||||
Sequence: CPPGYTGSRC | ||||||
Disulfide bond | 475↔486 | |||||
Sequence: CLSQPCHPGSTC | ||||||
Disulfide bond | 480↔495 | |||||
Sequence: CHPGSTCLDLLATFHC | ||||||
Disulfide bond | 497↔506 | |||||
Sequence: CPPGLEGQLC | ||||||
Disulfide bond | 513↔524 | |||||
Sequence: CASAPCLNHADC | ||||||
Disulfide bond | 518↔533 | |||||
Sequence: CLNHADCHDLLNGFQC | ||||||
Disulfide bond | 535↔544 | |||||
Sequence: CLPGFSGTRC | ||||||
Disulfide bond | 573↔582 | |||||
Sequence: CLPGFEGPRC | ||||||
Disulfide bond | 611↔620 | |||||
Sequence: CPSGFTGQLC | ||||||
Disulfide bond | 713↔722 | |||||
Sequence: CPTGYTGPTC | ||||||
Disulfide bond | 751↔760 | |||||
Sequence: CPPSHTGPQC | ||||||
Disulfide bond | 789↔798 | |||||
Sequence: CAMGFQGPRC | ||||||
Disulfide bond | 828↔837 | |||||
Sequence: CPTGYTGGSC | ||||||
Disulfide bond | 866↔875 | |||||
Sequence: CLQGWTGPLC | ||||||
Disulfide bond | 914↔923 | |||||
Sequence: CPPGFQGSLC | ||||||
Disulfide bond | 952↔961 | |||||
Sequence: CAPGYDGQNC | ||||||
Disulfide bond | 990↔999 | |||||
Sequence: CPPGFVGLRC | ||||||
Disulfide bond | 1011↔1028 | |||||
Sequence: CHPTGTAACHSLANAFYC | ||||||
Disulfide bond | 1030↔1039 | |||||
Sequence: CLPGHTGQWC | ||||||
Disulfide bond | 1071↔1080 | |||||
Sequence: CPKGFEGPTC | ||||||
Disulfide bond | 1112↔1121 | |||||
Sequence: CLSGYGGPDC | ||||||
Disulfide bond | 1157↔1166 | |||||
Sequence: CPHSSPGPRC |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, region, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 20-59 | EGF-like | ||||
Sequence: RGLLCGSFPEPCANGGTCLSLSLGQGTCQCAPGFLGETCQ | ||||||
Domain | 60-111 | EGF-like | ||||
Sequence: FPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPSFLCTCLPGFTGERCQ | ||||||
Domain | 114-151 | EGF-like | ||||
Sequence: LEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQCQ | ||||||
Domain | 152-188 | EGF-like | ||||
Sequence: LRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACE | ||||||
Domain | 190-228 | EGF-like | ||||
Sequence: DVNECFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCE | ||||||
Domain | 230-270 | EGF-like | ||||
Sequence: RAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIGPDCE | ||||||
Domain | 272-308 | EGF-like | ||||
Sequence: NPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCS | ||||||
Domain | 310-349 | EGF-like | ||||
Sequence: DVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCE | ||||||
Domain | 351-387 | EGF-like | ||||
Sequence: NLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLCH | ||||||
Domain | 388-426 | EGF-like | ||||
Sequence: LEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCH | ||||||
Domain | 428-469 | EGF-like | ||||
Sequence: DLDECLMAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCE | ||||||
Domain | 471-507 | EGF-like | ||||
Sequence: DHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCE | ||||||
Domain | 509-545 | EGF-like | ||||
Sequence: ETNECASAPCLNHADCHDLLNGFQCICLPGFSGTRCE | ||||||
Domain | 547-583 | EGF-like | ||||
Sequence: DIDECRSSPCANGGQCQDQPGAFHCKCLPGFEGPRCQ | ||||||
Domain | 585-621 | EGF-like | ||||
Sequence: EVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCE | ||||||
Domain | 687-723 | EGF-like | ||||
Sequence: ELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCS | ||||||
Domain | 725-761 | EGF-like | ||||
Sequence: EMTACHSGPCLNGGSCNPSPGGYYCTCPPSHTGPQCQ | ||||||
Domain | 763-799 | EGF-like | ||||
Sequence: STDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCE | ||||||
Domain | 802-838 | EGF-like | ||||
Sequence: LRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQ | ||||||
Domain | 840-876 | EGF-like | ||||
Sequence: LMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCN | ||||||
Domain | 889-924 | EGF-like | ||||
Sequence: QGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQGSLCQ | ||||||
Domain | 926-962 | EGF-like | ||||
Sequence: HVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCS | ||||||
Domain | 964-1000 | EGF-like | ||||
Sequence: ELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCE | ||||||
Domain | 1002-1040 | EGF-like | ||||
Sequence: DVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCE | ||||||
Domain | 1042-1081 | EGF-like | ||||
Sequence: EIDPCHSQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCS | ||||||
Domain | 1083-1122 | EGF-like | ||||
Sequence: RAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCL | ||||||
Domain | 1126-1167 | EGF-like | ||||
Sequence: APKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQ | ||||||
Domain | 1166-1209 | LNR | ||||
Sequence: CQKPGAKGCEGRSGDGACDAGCSGPGGNWDGGDCSLGVPDPWKG | ||||||
Domain | 1210-1246 | LNR | ||||
Sequence: CPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPA | ||||||
Domain | 1247-1290 | LNR | ||||
Sequence: CTPAYDQYCHDHFHNGHCEKGCNTAECGWDGGDCRPEDGDPEWG | ||||||
Region | 1336-1367 | Disordered | ||||
Sequence: YPYPGAPAEEKLGGTRDPTYQERAAPQTQPLG | ||||||
Region | 1481-1504 | Disordered | ||||
Sequence: PGFTRRPRTQSAPHRRRPPLGEDS | ||||||
Repeat | 1629-1661 | ANK | ||||
Sequence: TGETPLHLAARFSRPTAARRLLEAGANPNQPDR | ||||||
Repeat | 1662-1684 | ANK | ||||
Sequence: AGRTPLHAAVAADAREVCQLLLR | ||||||
Repeat | 1696-1728 | ANK | ||||
Sequence: DGTTPLMLAARLAVEDLVEELIAAQADVGARDK | ||||||
Repeat | 1729-1761 | ANK | ||||
Sequence: WGKTALHWAAAVNNARAARSLLQAGADKDAQDN | ||||||
Repeat | 1762-1794 | ANK | ||||
Sequence: REQTPLFLAAREGAVEVAQLLLGLGAARELRDQ | ||||||
Region | 1896-1923 | Disordered | ||||
Sequence: LSGVGAGGGPTPRGRRFSAGMRGPRPNP | ||||||
Region | 1964-1999 | Disordered | ||||
Sequence: PPPCLTPSPERGSPQLDCGPPALQEMPINQGGEGKK |
Sequence similarities
Belongs to the NOTCH family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,999
- Mass (Da)209,110
- Last updated2017-08-30 v2
- Checksum2DB4401892BB557B