A0A1U9X8X3 · A0A1U9X8X3_HUMAN

Function

function

Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Selective cleavage of Arg-|-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg-|-Xaa bond in complement component C5 alpha-chain to form C5a and C5b.
    EC:3.4.21.43 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

1752100200300400500600700
TypeIDPosition(s)Description
Active site507Charge relay system
Active site561Charge relay system
Active site679Charge relay system

GO annotations

AspectTerm
Cellular Componentclassical-complement-pathway C3/C5 convertase complex
Cellular Componentextracellular exosome
Molecular Functionserine-type endopeptidase activity
Biological Processcomplement activation, classical pathway
Biological Processinnate immune response
Biological Processproteolysis
Biological Processresponse to bacterium

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Complement C2
  • EC number
  • Alternative names
    • C3/C5 convertase

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1U9X8X3

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_501072106521-752Complement C2
Disulfide bond117↔144
Disulfide bond177↔204

Keywords

Proteomic databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-86Sushi
Domain87-146Sushi
Domain149-206Sushi
Domain254-452VWFA
Domain464-744Peptidase S1

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    752
  • Mass (Da)
    83,254
  • Last updated
    2017-06-07 v1
  • Checksum
    4FD31149AB53ABAB
MGPLMVLFCLLFLYPGLADSAPSCPQNVNISGGTFTLSHGWAPGSLLTYSCPQGLYPSPASRLCKSSGQWQTPGATRSLSKAVCKPVRCPAPVSFENGIYTPRLGSYPVGGNVSFECEDGFILRGSPVRQCRPNGMWDGETAVCDNGAGHCPNPGISLGAVRTGFRFGHGDKVRYRCSSNLVLTGSSERECQGNGVWSGTEPICRQPYSYDFPEDVAPALGTSFSHMLGATNPTQKTKESLGRKIQIQRSGHLNLYLLLDCSQSVSENDFLIFKESASLMVDRIFSFEINVSVAIITFASEPKVLMSVLNDNSRDMTDVISSLENANYKDHENGTGTNTYAALNSVYLMMNNQMRLLGMETMAWQEIRHAIILLTDGKSNMGGSPKTAVDHIREILNINQKRNDYLDIYAIGVGKLDVDWRELNELGSKKDGERHAFILQDTKALHQVFEHMLDVSKLTDTICGVGNMSANASDQERTPWHVTIKPKSQETCRGALISDQWVLTAAHCFRDGNDHSLWRVNVGDPKSQWGKEFLIEKAVISPGFDVFAKKNQGILEFYGDDIALLKLAQKVKMSTHARPICLPCTMEANLALRRPQGSTCRDHENELLNKQSVPAHFVALNGSKLNINLKMGVEWTSCAEVVSQEKTMFPNLTDVREVVTDQFLCSGTQEDESPCKGESGGAVFLERRFRFFQVGLVSWGLYNPCLGSADKNSRKRAPRSKVPPPRDFHINLFRMQPWLRQHLGDVLNFLPL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KY500772
EMBL· GenBank· DDBJ
AQY77242.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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