A0A1U9JWZ1 · A0A1U9JWZ1_9HYPH

Function

function

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular Functiondihydrofolate synthase activity
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processfolic acid biosynthetic process
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrofolate synthase/folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase
    • Folylpolyglutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • ORF names
      BHV28_17100

Organism names

Accessions

  • Primary accession
    A0A1U9JWZ1

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain47-268Mur ligase central
Domain310-425Mur ligase C-terminal

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    441
  • Mass (Da)
    47,419
  • Last updated
    2017-06-07 v1
  • Checksum
    B439A92482FB2918
MAETADHYIKALLDVYPKGVDLSLTRIGRLLSDLGNPHLQLPPVIHIAGTNGKGSAGAFCRALLEAAGLRVHVHTSPHLVHVHERYRIGRLNGGHYVDDAELLEILQHITTVNDQQPITVFEIITAAAFVLFARHPADAVILEVGLGGRFDATNIIPEPAVSLIMPVALDHQAFLGDTVEQIAFEKAGIIKDSTPVVIGFQAYDGARDVLLRQAEKHKAPVAVYGQDFSACVEHGRMAVQSNRGLLDLPRPRLVGDFQLGNAAAAIEAVYAAGFHLDETTIATAMQKVEWPARMQKLHQGHLKTLLPQQTDLWLDGGHNPAAAQVTSAAMRLLCQQQNRKLALVCGMISTKDSNHYLEAFKGLAERVYTVPVHFSEAGVPADLLAQAARGLGFEAQGFDTIAGAFTAINADYATLPAPVVLVSGSLYLAGEVLQQNGTKPV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP017315
EMBL· GenBank· DDBJ
AQS42380.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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