A0A1U8QYZ5 · SMTA_EMENI

Function

function

Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position (PubMed:27479571).
Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates (By similarity).
Glucosylceramides play important roles in growth, differentiation and pathogenicity (PubMed:27479571).
The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses (By similarity).

Catalytic activity

Pathway

Lipid metabolism; sphingolipid metabolism.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site223-224S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site286-291S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site316-317S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmembrane
Molecular Functionmethyltransferase activity
Biological Processmethylation
Biological Processsphingolipid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sphingolipid C9-methyltransferase A
  • EC number

Gene names

    • Name
      smtA
    • ORF names
      AN5688, ANIA_05688

Organism names

Accessions

  • Primary accession
    A0A1U8QYZ5
  • Secondary accessions
    • C8VFQ5
    • Q5B192

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane58-78Helical
Transmembrane80-100Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Leads to increased resistance to cell-wall-damaging agents, such as calcofluor white (CFW) and Congo red (CR) (PubMed:27479571).
Accumulates unmethylated glucosylceramides (PubMed:27479571).

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00004571671-517Sphingolipid C9-methyltransferase A
Glycosylation290N-linked (GlcNAc...) asparagine
Glycosylation478N-linked (GlcNAc...) asparagine

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the CFA/CMAS family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    517
  • Mass (Da)
    58,155
  • Last updated
    2017-05-10 v1
  • Checksum
    F7056395EC048F2E
MTNIHPESPEDFEFIETPAASCTTPADDCGVRTTSYPAIKNAPVPADAAGSDSFSNTLLILLLVVIPWYTARQIGGGLKTTIFFAIFTTIPILMAFWSIASSISPRKNEKAKYAGRPVEHYLHFHSEHDRATYRGKSKIPMEVFYEKYFAGEVDFKMDALEALEFRHDWANFRFTMGLFKHFLFGFIPELLVHSRSQDEEQVRDHYDRGDDFYAWFLGPRMIYTSGIISDIKKEETLEQLQDNKLAVVCEKVGLKPGDTVLDLGCGWGTLAKYASVHYGAQVTGITLGRNQTAWGNKGLRAAGIDESQSRILCMDYRDAPRVPGGYKKITCLEMAEHVGVRHFGSFLAQVNEMLDDDGVFFLQIAGLRKSWQYEDLIWGLFMNKYIFPGADASTPLGFVVDKLEAAGFEIKGIDTIGVHYSATLWRWYRNWLGNGEKVKAKYGERWYRIWEYFLAYSTITSRQGGATCWQITLVKNINSTHRVEGINSQYGLTGAREAAIASVGKGSLPSAHVTFKA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACD01000098
EMBL· GenBank· DDBJ
EAA62781.1
EMBL· GenBank· DDBJ
Genomic DNA
BN001305
EMBL· GenBank· DDBJ
CBF81402.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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