A0A1U8QYZ5 · SMTA_EMENI
- ProteinSphingolipid C9-methyltransferase A
- GenesmtA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids517 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position (PubMed:27479571).
Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates (By similarity).
Glucosylceramides play important roles in growth, differentiation and pathogenicity (PubMed:27479571).
The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses (By similarity).
Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates (By similarity).
Glucosylceramides play important roles in growth, differentiation and pathogenicity (PubMed:27479571).
The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses (By similarity).
Catalytic activity
- a (4E,8E)-4-sphinga-4,8-dienine ceramide + S-adenosyl-L-methionine = a 9-methyl-(4E,8E)-sphinga-4,8-dienine ceramide + H+ + S-adenosyl-L-homocysteineThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; sphingolipid metabolism.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Molecular Function | methyltransferase activity | |
Biological Process | methylation | |
Biological Process | sphingolipid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSphingolipid C9-methyltransferase A
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes
Accessions
- Primary accessionA0A1U8QYZ5
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 58-78 | Helical | ||||
Sequence: LLILLLVVIPWYTARQIGGGL | ||||||
Transmembrane | 80-100 | Helical | ||||
Sequence: TTIFFAIFTTIPILMAFWSIA |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000457167 | 1-517 | Sphingolipid C9-methyltransferase A | |||
Sequence: MTNIHPESPEDFEFIETPAASCTTPADDCGVRTTSYPAIKNAPVPADAAGSDSFSNTLLILLLVVIPWYTARQIGGGLKTTIFFAIFTTIPILMAFWSIASSISPRKNEKAKYAGRPVEHYLHFHSEHDRATYRGKSKIPMEVFYEKYFAGEVDFKMDALEALEFRHDWANFRFTMGLFKHFLFGFIPELLVHSRSQDEEQVRDHYDRGDDFYAWFLGPRMIYTSGIISDIKKEETLEQLQDNKLAVVCEKVGLKPGDTVLDLGCGWGTLAKYASVHYGAQVTGITLGRNQTAWGNKGLRAAGIDESQSRILCMDYRDAPRVPGGYKKITCLEMAEHVGVRHFGSFLAQVNEMLDDDGVFFLQIAGLRKSWQYEDLIWGLFMNKYIFPGADASTPLGFVVDKLEAAGFEIKGIDTIGVHYSATLWRWYRNWLGNGEKVKAKYGERWYRIWEYFLAYSTITSRQGGATCWQITLVKNINSTHRVEGINSQYGLTGAREAAIASVGKGSLPSAHVTFKA | ||||||
Glycosylation | 290 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 478 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length517
- Mass (Da)58,155
- Last updated2017-05-10 v1
- ChecksumF7056395EC048F2E
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AACD01000098 EMBL· GenBank· DDBJ | EAA62781.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BN001305 EMBL· GenBank· DDBJ | CBF81402.1 EMBL· GenBank· DDBJ | Genomic DNA |