A0A1U8QVI3 · MSCB_EMENI
- ProteinMechanosensitive ion channel protein BA
- GenemscB
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids943 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Acts as a mechanosensitive calcium channel in response to membrane stretch (By similarity).
Regulates intracellular calcium levels and cell volume for survival in response to hypo-osmotic shock (By similarity).
Involved in maintaining vacuole integrity and protecting the nuclear envelope upon hypo-osmotic shock (By similarity).
seems to contribute to CaCl2 toxicityIn contracstz to mscA, mscB seems to contribute to CaCl2 toxicity (PubMed:35941834).
Regulates intracellular calcium levels and cell volume for survival in response to hypo-osmotic shock (By similarity).
Involved in maintaining vacuole integrity and protecting the nuclear envelope upon hypo-osmotic shock (By similarity).
seems to contribute to CaCl2 toxicityIn contracstz to mscA, mscB seems to contribute to CaCl2 toxicity (PubMed:35941834).
Catalytic activity
- Ca2+(in) = Ca2+(out)
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 425 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 427 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 429 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 431 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 436 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | calcium channel activity | |
Molecular Function | calcium ion binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameMechanosensitive ion channel protein BA
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Aspergillus > Aspergillus subgen. Nidulantes
Accessions
- Primary accessionA0A1U8QVI3
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-107 | Cytoplasmic | |||
Transmembrane | 108-130 | Helical | |||
Topological domain | 131-149 | Lumenal | |||
Transmembrane | 150-175 | Helical | |||
Topological domain | 176-195 | Cytoplasmic | |||
Transmembrane | 196-214 | Helical | |||
Topological domain | 215-233 | Lumenal | |||
Transmembrane | 234-259 | Helical | |||
Topological domain | 260-468 | Cytoplasmic | |||
Transmembrane | 469-489 | Helical | |||
Topological domain | 490-502 | Lumenal | |||
Transmembrane | 503-523 | Helical | |||
Topological domain | 524-943 | Cytoplasmic | |||
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Does not affect growth, morphology and rate of germination of germlings under normal or hypotonic conditions.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000457336 | 1-943 | Mechanosensitive ion channel protein BA | ||
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-40 | Polar residues | |||
Region | 1-67 | Disordered | |||
Domain | 412-447 | EF-hand | |||
Region | 677-943 | Disordered | |||
Compositional bias | 686-701 | Basic and acidic residues | |||
Compositional bias | 744-780 | Polar residues | |||
Compositional bias | 810-845 | Polar residues | |||
Compositional bias | 859-905 | Polar residues | |||
Compositional bias | 919-943 | Basic and acidic residues | |||
Domain
EF-hand domain is involved in the detection of calcium concentration.
Sequence similarities
Belongs to the MscS (TC 1.A.23) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length943
- Mass (Da)103,476
- Last updated2017-05-10 v1
- ChecksumD04F9E960A599607
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-40 | Polar residues | |||
Compositional bias | 686-701 | Basic and acidic residues | |||
Compositional bias | 744-780 | Polar residues | |||
Compositional bias | 810-845 | Polar residues | |||
Compositional bias | 859-905 | Polar residues | |||
Compositional bias | 919-943 | Basic and acidic residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AACD01000104 EMBL· GenBank· DDBJ | EAA58028.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BN001301 EMBL· GenBank· DDBJ | CBF70280.1 EMBL· GenBank· DDBJ | Genomic DNA |