A0A1U8QVI3 · MSCB_EMENI

Function

function

Acts as a mechanosensitive calcium channel in response to membrane stretch (By similarity).
Regulates intracellular calcium levels and cell volume for survival in response to hypo-osmotic shock (By similarity).
Involved in maintaining vacuole integrity and protecting the nuclear envelope upon hypo-osmotic shock (By similarity).
seems to contribute to CaCl2 toxicityIn contracstz to mscA, mscB seems to contribute to CaCl2 toxicity (PubMed:35941834).

Catalytic activity

Features

Showing features for binding site.

1943100200300400500600700800900
TypeIDPosition(s)Description
Binding site425Ca2+ (UniProtKB | ChEBI)
Binding site427Ca2+ (UniProtKB | ChEBI)
Binding site429Ca2+ (UniProtKB | ChEBI)
Binding site431Ca2+ (UniProtKB | ChEBI)
Binding site436Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functioncalcium channel activity
Molecular Functioncalcium ion binding

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 1.A.23.4.17the small conductance mechanosensitive ion channel (mscs) family

Names & Taxonomy

Protein names

  • Recommended name
    Mechanosensitive ion channel protein BA
  • EC number

Gene names

    • Name
      mscB
    • ORF names
      AN6053.2, ANIA_06053

Organism names

Accessions

  • Primary accession
    A0A1U8QVI3
  • Secondary accessions
    • C8V2U9
    • Q5B077

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-107Cytoplasmic
Transmembrane108-130Helical
Topological domain131-149Lumenal
Transmembrane150-175Helical
Topological domain176-195Cytoplasmic
Transmembrane196-214Helical
Topological domain215-233Lumenal
Transmembrane234-259Helical
Topological domain260-468Cytoplasmic
Transmembrane469-489Helical
Topological domain490-502Lumenal
Transmembrane503-523Helical
Topological domain524-943Cytoplasmic

Keywords

Phenotypes & Variants

Disruption phenotype

Does not affect growth, morphology and rate of germination of germlings under normal or hypotonic conditions.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004573361-943Mechanosensitive ion channel protein BA

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-40Polar residues
Region1-67Disordered
Domain412-447EF-hand
Region677-943Disordered
Compositional bias686-701Basic and acidic residues
Compositional bias744-780Polar residues
Compositional bias810-845Polar residues
Compositional bias859-905Polar residues
Compositional bias919-943Basic and acidic residues

Domain

EF-hand domain is involved in the detection of calcium concentration.

Sequence similarities

Belongs to the MscS (TC 1.A.23) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    943
  • Mass (Da)
    103,476
  • Last updated
    2017-05-10 v1
  • Checksum
    D04F9E960A599607
MPNPNDVTIDIPLTSVSSRGQTGARNNSTNIPNSPSGGYSAGAEHNGGAEKGGLTSSPPSSSLGFGHRRRRTINDKTGLPAEEPEDGTVTRMGRFYQAVLNFSTVTRYLIYIAPLAALLAIPIIVGATAAEDAKIGGVSLPWFFCWVEVVWVSLWVCKLVAKVIPFVFQFVCGIVSAGTRKYALILRNLEIPITMVLWMIVSLVTFLPIMVYNPRNKREGDTETKSWEKSVKNVLFAFLVCALIFLGEKTLVQLISISYHRKQFDARIKESKRNINLIGILYDASRSMFPMYCKEFREDDAIISDSILLGGPETGRPGHSRSNSAAPLRFIRGVQQNVGRIGGKITGALGDVAHEITGKQVFNSSAARSIVSEALERRRSSEALARRIWMSFVIEGREALYLDDIMEVLGAGKEAEAEECFTMLDRDGNGDISLDEIILAISEIGRTRKTLNHSVHDVDQAIHVLDNLLATIAFIIAVLVFVSFVTSGFGTVIAAGATSLLSLSFVFATTAQEVLGSCIFLFVKHPFDIGDRVEIDSKPYIVQRISLLYSVFRNVNDNRVTQIPNVVLNTVWIDNYSRSSAMQEKLTIEVNIDTTTEEIQALKDEIETFVRSPDNKRDFHPDVDIEVSGVGALDKLELTVGLFHKSNWAIESVRAARRSKFMVALVAAVKKVPIRTPGAAAEDAAAADGDRPDDKPDDAEQPPARQSSISEGIRHPTVPDDSFPSDSKSTGVDLGRPGSVQRRGASATAATGNNSAGSAYSETTLNNTVSEPYQRSFTPNTGDRDTDHYHGSMSSPVTERHLGVSHDSIARKASTASTGRRRAGIMTTANQSLASPTTMQSESALPPHLQPPPPLQPSSSQYSQQYPQQQSQSPYSYTYSERYDQPESSLQPLEHTTSYNQSLPQVYEYAPAADRNSLEGHSPHVDPRHMTEEQRRNYESRRL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias1-40Polar residues
Compositional bias686-701Basic and acidic residues
Compositional bias744-780Polar residues
Compositional bias810-845Polar residues
Compositional bias859-905Polar residues
Compositional bias919-943Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AACD01000104
EMBL· GenBank· DDBJ
EAA58028.1
EMBL· GenBank· DDBJ
Genomic DNA
BN001301
EMBL· GenBank· DDBJ
CBF70280.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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