A0A1U7QXR8 · A0A1U7QXR8_MESAU

Function

Features

Showing features for active site, binding site.

133450100150200250300
TypeIDPosition(s)Description
Active site133Proton acceptor
Binding site141Zn2+ (UniProtKB | ChEBI)
Binding site144Zn2+ (UniProtKB | ChEBI)
Binding site166Zn2+ (UniProtKB | ChEBI)
Binding site177Zn2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, subtelomeric region
Cellular Componentendoplasmic reticulum
Cellular Componentnucleoplasm
Cellular Componentpericentric heterochromatin
Cellular Componentsite of double-strand break
Molecular Functionchromatin DNA binding
Molecular Functiondamaged DNA binding
Molecular FunctionDNA damage sensor activity
Molecular FunctionlncRNA binding
Molecular Functionmetal ion binding
Molecular FunctionNAD+ binding
Molecular FunctionNAD+-protein-arginine ADP-ribosyltransferase activity
Molecular FunctionNAD-dependent histone H3K18 deacetylase activity
Molecular FunctionNAD-dependent histone H3K56 deacetylase activity
Molecular FunctionNAD-dependent histone H3K9 deacetylase activity
Molecular FunctionNAD-dependent protein demyristoylase activity
Molecular FunctionNAD-dependent protein depalmitoylase activity
Molecular Functionnucleosome binding
Molecular Functionprotein homodimerization activity
Molecular FunctionTORC2 complex binding
Molecular Functiontranscription corepressor activity
Biological Processbase-excision repair
Biological Processcardiac muscle cell differentiation
Biological Processcircadian regulation of gene expression
Biological Processdetermination of adult lifespan
Biological ProcessDNA repair-dependent chromatin remodeling
Biological Processdouble-strand break repair
Biological Processglucose homeostasis
Biological Processketone biosynthetic process
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of cellular senescence
Biological Processnegative regulation of gluconeogenesis
Biological Processnegative regulation of glucose import
Biological Processnegative regulation of glycolytic process
Biological Processnegative regulation of protein import into nucleus
Biological Processnegative regulation of protein localization to chromatin
Biological Processnegative regulation of transcription by RNA polymerase II
Biological Processnegative regulation of transcription elongation by RNA polymerase II
Biological Processpericentric heterochromatin formation
Biological Processpositive regulation of blood vessel branching
Biological Processpositive regulation of chondrocyte proliferation
Biological Processpositive regulation of cold-induced thermogenesis
Biological Processpositive regulation of double-strand break repair
Biological Processpositive regulation of fat cell differentiation
Biological Processpositive regulation of fibroblast proliferation
Biological Processpositive regulation of insulin secretion
Biological Processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
Biological Processpositive regulation of protein export from nucleus
Biological Processpositive regulation of protein localization to chromatin
Biological Processpositive regulation of stem cell differentiation
Biological Processpositive regulation of stem cell population maintenance
Biological Processpositive regulation of stem cell proliferation
Biological Processpositive regulation of telomere maintenance
Biological Processpositive regulation of vascular endothelial cell proliferation
Biological Processprotein destabilization
Biological Processprotein localization to site of double-strand break
Biological Processregulation of circadian rhythm
Biological Processregulation of double-strand break repair via homologous recombination
Biological Processregulation of lipid catabolic process
Biological Processregulation of protein localization to plasma membrane
Biological Processresponse to UV
Biological Processretrotransposon silencing
Biological Processsubtelomeric heterochromatin formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    protein acetyllysine N-acetyltransferase
  • EC number

Gene names

    • Name
      Sirt6

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Cricetidae > Cricetinae > Mesocricetus

Accessions

  • Primary accession
    A0A1U7QXR8

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain27-272Deacetylase sirtuin-type
Region289-334Disordered

Sequence similarities

Belongs to the sirtuin family. Class IV subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    334
  • Mass (Da)
    36,588
  • Last updated
    2017-05-10 v1
  • Checksum
    DDA75846450D234C
MSVNYAAGLSPYADKGKCGLPEVFDPPEELERKVRELARLVRQSPRVVFHTGAGISTACGIPDFRGPHGVWTMEERGLAPKFDTTFESARPSKTHMALVQLERAGFLSFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECPKCKMQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDALPERDLMRADEASRTADLSVTLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRQADLRIHGYVDEVMSGLMKHLGLEIPAWDGPCVLDKALPPLPRPAAPKTEPPAHLNGSVHAACKPEPNSSVPHRPPKRVKTEAAPS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A3Q0DDA2A0A3Q0DDA2_MESAUSirt6307

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MK482076
EMBL· GenBank· DDBJ
QBK17529.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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