A0A1T3A6H0 · A0A1T3A6H0_PSEFL

Function

function

Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site11-16substrate
Binding site42Mg2+ (UniProtKB | ChEBI)
Active site71Proton acceptor
Binding site71Mg2+ (UniProtKB | ChEBI)
Binding site72substrate
Binding site155-158substrate
Binding site178substrate
Binding site183-184substrate

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular Functionribonucleoside triphosphate phosphatase activity
Molecular FunctionXTP diphosphatase activity
Biological Processnucleotide metabolic process
Biological Processpurine nucleoside triphosphate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    dITP/XTP pyrophosphatase
  • EC number
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • Name
      rdgB
    • ORF names
      NCTC10038_05738

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NCTC10038
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    A0A1T3A6H0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    21,339
  • Last updated
    2017-05-10 v1
  • Checksum
    E35CAB02D4C349B7
MMNLTQLVLASHNAGKLKELQAMLGESVQLRSIGEFSQVEPEETGLSFVENAILKARNAARISGLPALADDSGLAVDYLGGAPGIYSARYADGKGDAANNAKLLDALKEVPDAMRGAQFVCVLALVRHADDPLPILCEGLWHGRILHAASGEHGFGYDPLFWVPERNVSSAELSPADKNQISHRARAMDLLRQRLSLK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LS483372
EMBL· GenBank· DDBJ
SQF96064.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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