A0A1T0APK5 · A0A1T0APK5_9PAST

  • Protein
    Energy-dependent translational throttle protein EttA
  • Gene
    ettA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Features

Showing features for binding site.

155650100150200250300350400450500550
TypeIDPosition(s)Description
Binding site40-47ATP 1 (UniProtKB | ChEBI)
Binding site357-364ATP 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionribosome binding
Molecular FunctionrRNA binding
Molecular FunctiontRNA binding
Biological Processnegative regulation of translational elongation
Biological Processtranslation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Energy-dependent translational throttle protein EttA
  • EC number
  • Alternative names
    • Translational regulatory factor EttA

Gene names

    • Name
      ettA
    • ORF names
      B0187_09265

Organism names

  • Taxonomic identifier
  • Strain
    • CCUG 43573
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pasteurellales > Pasteurellaceae > Haemophilus

Accessions

  • Primary accession
    A0A1T0APK5

Proteomes

Subcellular Location

Cytoplasm
Note: Associates with ribosomes and polysomes.

Keywords

Interaction

Subunit

Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain7-261ABC transporter
Region96-140Arm
Region243-323PtIM
Domain325-551ABC transporter

Domain

The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.
The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    556
  • Mass (Da)
    62,530
  • Last updated
    2017-05-10 v1
  • Checksum
    488FB88815C1A0F2
MSTQFVYTMHRVGKVVPPKRHILKDISLSFFPGAKIGVLGLNGAGKSTLLRIMAGIDKEIEGEARPQPGIKIGYLPQEPKLEPQQTVREAIEEAVGEVKKALTRLDEVYALYADPDADFDKLAAEQAELEAIIQAHDGHNLDNQLERAADALRLPDWDAKIEHLSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAESVAWLERFLHDYEGTVVAITHDRYFLDNVAGWILELDRGEGIPWEGNYSSWLEQKEKRLAQEQAAESARQKSIEKELEWVRQNPKGRQAKSKARMARFEELNSGEYQKRNETNELFIPPGPRLGDKVIEVQNLTKSYGDRTLIDDLSFSIPKGAIVGIIGANGAGKSTLFRMLSGKEQPDSGSIVLGETVVMASVDQFRDAMDDKKTVWEEVSGGQDIMRIGNFEIPSRAYVGRFNFKGVDQQKRVGELSGGERGRLHLAKLLQVGGNVLLLDEPTNDLDVETLRALENAILEFPGCALVISHDRWFLDRIATHILDYGDEGKVTFYEGNFSDYEEWKKKTYGEAATQPHRIKYKRIAK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
MUYA01000018
EMBL· GenBank· DDBJ
OOR98126.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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