A0A1S9RD80 · A0A1S9RD80_PENBI

Function

function

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site33-52NAD+ (UniProtKB | ChEBI)
Binding site77substrate
Binding site80substrate
Binding site111-114NAD+ (UniProtKB | ChEBI)
Active site131Proton acceptor
Binding site139Zn2+ (UniProtKB | ChEBI)
Binding site144Zn2+ (UniProtKB | ChEBI)
Binding site218Zn2+ (UniProtKB | ChEBI)
Binding site221Zn2+ (UniProtKB | ChEBI)
Binding site260-262NAD+ (UniProtKB | ChEBI)
Binding site286-288NAD+ (UniProtKB | ChEBI)
Binding site307NAD+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Cellular Componentnucleus
Molecular FunctionNAD+ binding
Molecular FunctionNAD-dependent histone deacetylase activity
Molecular Functionprotein-glutaryllysine deglutarylase activity
Molecular Functionprotein-malonyllysine demalonylase activity
Molecular Functionprotein-succinyllysine desuccinylase activity
Molecular Functiontransferase activity
Molecular Functionzinc ion binding
Biological Processprotein deacetylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    NAD-dependent protein deacylase
  • EC number
  • Alternative names
    • Regulatory protein SIR2 homolog 5

Gene names

    • ORF names
      PEBR_34317

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • LaBioMMi 136
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Penicillium

Accessions

  • Primary accession
    A0A1S9RD80

Proteomes

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain8-322Deacetylase sirtuin-type
Region162-183Disordered

Domain

In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-77 and Arg-80) that bind to malonylated and succinylated substrates and define the specificity.

Sequence similarities

Belongs to the sirtuin family. Class I subfamily.
Belongs to the sirtuin family. Class III subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    322
  • Mass (Da)
    35,186
  • Last updated
    2017-05-10 v1
  • Checksum
    25D744DCEDFDC4D8
MASKANKVIAPSTDIQSFAEYLKGCRRILALLGAGISAASGLPTFRGAGGLWRQYDATSLATPEAFADHPGLVWQFYSYRRHMALQAQPNKAHYALAELARRNKDFITLSQNVDGLSQRAQHPSEQLNLLHGSLFDIKCTSFYCNYTRQNDFTDPIVPALDIPKQSSSPIPSETDRTGEEASKSLHDALQETIQANEVDISDASNPIPKLAPADLPRCPECKGLLRPGVIWFGEPLPTDTIKNVDDWIESAPVDLILVIGTSSSVYPAALYVDVARERGAKVVVVNMEKDMPNRGQGSCDWFFQGDASVIVPEILKSVIGDV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LJBN01000195
EMBL· GenBank· DDBJ
OOQ83489.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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