A0A1S7SKC8 · A0A1S7SKC8_HUMAN

  • Protein
    HLA class I histocompatibility antigen A alpha chain
  • Gene
    HLA-A
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentearly endosome membrane
Cellular ComponentER to Golgi transport vesicle membrane
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular space
Cellular Componentlumenal side of endoplasmic reticulum membrane
Cellular Componentphagocytic vesicle membrane
Cellular Componentrecycling endosome membrane
Molecular Functionpeptide antigen binding
Molecular Functionsignaling receptor binding
Biological Processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
Biological Processantigen processing and presentation of endogenous peptide antigen via MHC class Ib
Biological Processimmune response
Biological Processpositive regulation of T cell mediated cytotoxicity

Names & Taxonomy

Protein names

  • Submitted names
    • HLA class I histocompatibility antigen A alpha chain
    • MHC HLA-A cell surface glycoprotein
    • MHC class I antigen

Gene names

    • Name
      HLA-A

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    A0A1S7SKC8

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane308-332Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-24
ChainPRO_503328234625-365

Keywords

Proteomic databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain209-295Ig-like
Region338-365Disordered
Compositional bias341-359Polar residues

Sequence similarities

Belongs to the MHC class I family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    365
  • Mass (Da)
    41,061
  • Last updated
    2017-05-10 v1
  • Checksum
    9779C71BCF388614
MAVMAPRTLVLLLSGALALTQTWAGSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDRNTRNVKAHSQTDRANLGTLRGYYNQSEDGSHTIQRMYGCDVGPDGRFLRGYQQNAYDGKDYIALNEDLRSWTAADMAAQITQRKWETAHEAEQWRAYLEGRCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWASVVVPSGQEQRYTCHVQHEGLPKPLTLRWEPSSQPTIPIVGIIAGLVLFGAVIAGAVVAAVMWRRKSSDRKGGSYSQAASSDSAQGSDMSLTACKV

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias341-359Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M98453
EMBL· GenBank· DDBJ
AAA35991.1
EMBL· GenBank· DDBJ
mRNA
LC257697
EMBL· GenBank· DDBJ
BBD34015.1
EMBL· GenBank· DDBJ
Genomic DNA
LC326126
EMBL· GenBank· DDBJ
BBD74362.1
EMBL· GenBank· DDBJ
Genomic DNA
LN999847
EMBL· GenBank· DDBJ
CUX96938.1
EMBL· GenBank· DDBJ
Genomic DNA
MN557833
EMBL· GenBank· DDBJ
QHQ71284.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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