A0A1S7SKC8 · A0A1S7SKC8_HUMAN
- ProteinHLA class I histocompatibility antigen A alpha chain
- GeneHLA-A
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids365 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | early endosome membrane | |
Cellular Component | ER to Golgi transport vesicle membrane | |
Cellular Component | external side of plasma membrane | |
Cellular Component | extracellular space | |
Cellular Component | lumenal side of endoplasmic reticulum membrane | |
Cellular Component | phagocytic vesicle membrane | |
Cellular Component | recycling endosome membrane | |
Molecular Function | peptide antigen binding | |
Molecular Function | signaling receptor binding | |
Biological Process | antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent | |
Biological Process | antigen processing and presentation of endogenous peptide antigen via MHC class Ib | |
Biological Process | immune response | |
Biological Process | positive regulation of T cell mediated cytotoxicity |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionA0A1S7SKC8
Subcellular Location
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 308-332 | Helical | ||||
Sequence: IVGIIAGLVLFGAVIAGAVVAAVMW |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MAVMAPRTLVLLLSGALALTQTWA | ||||||
Chain | PRO_5033282346 | 25-365 | ||||
Sequence: GSHSMRYFYTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDRNTRNVKAHSQTDRANLGTLRGYYNQSEDGSHTIQRMYGCDVGPDGRFLRGYQQNAYDGKDYIALNEDLRSWTAADMAAQITQRKWETAHEAEQWRAYLEGRCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWASVVVPSGQEQRYTCHVQHEGLPKPLTLRWEPSSQPTIPIVGIIAGLVLFGAVIAGAVVAAVMWRRKSSDRKGGSYSQAASSDSAQGSDMSLTACKV |
Keywords
- PTM
Proteomic databases
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 209-295 | Ig-like | ||||
Sequence: PKTHMTHHAVSDHEATLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWASVVVPSGQEQRYTCHVQHEGLPKPLT | ||||||
Region | 338-365 | Disordered | ||||
Sequence: DRKGGSYSQAASSDSAQGSDMSLTACKV | ||||||
Compositional bias | 341-359 | Polar residues | ||||
Sequence: GGSYSQAASSDSAQGSDMS |
Sequence similarities
Belongs to the MHC class I family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length365
- Mass (Da)41,061
- Last updated2017-05-10 v1
- Checksum9779C71BCF388614
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 341-359 | Polar residues | ||||
Sequence: GGSYSQAASSDSAQGSDMS |
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M98453 EMBL· GenBank· DDBJ | AAA35991.1 EMBL· GenBank· DDBJ | mRNA | ||
LC257697 EMBL· GenBank· DDBJ | BBD34015.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LC326126 EMBL· GenBank· DDBJ | BBD74362.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LN999847 EMBL· GenBank· DDBJ | CUX96938.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MN557833 EMBL· GenBank· DDBJ | QHQ71284.1 EMBL· GenBank· DDBJ | Genomic DNA |