A0A1S6WSI0 · A0A1S6WSI0_9HYPH

  • Protein
    Bifunctional protein FolD
  • Gene
    folD
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.

Catalytic activity

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site168-170NADP+ (UniProtKB | ChEBI)
Binding site193NADP+ (UniProtKB | ChEBI)
Binding site234NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmethenyltetrahydrofolate cyclohydrolase activity
Molecular Functionmethylenetetrahydrofolate dehydrogenase (NADP+) activity
Biological ProcessL-histidine biosynthetic process
Biological Processmethionine biosynthetic process
Biological Processpurine nucleotide biosynthetic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional protein FolD

Including 2 domains:

  • Recommended name
    Methylenetetrahydrofolate dehydrogenase
  • EC number
  • Recommended name
    Methenyltetrahydrofolate cyclohydrolase
  • EC number

Gene names

    • Name
      folD
    • ORF names
      BWD162_001340

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • WD16.2
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Bartonellaceae > Bartonella

Accessions

  • Primary accession
    A0A1S6WSI0

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-120Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic
Domain123-290Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding

Sequence similarities

Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    299
  • Mass (Da)
    32,340
  • Last updated
    2017-05-10 v1
  • Checksum
    1D60358033D6FF2F
MNNIIDGKKLAENIINKIKKETKKLRNNHKIQPGIAVIIVGDDPASQVYVTSKSKKAEECGFLSIKHTIPQDTKEEELLQLIETLNSDPKIHGILVQLPLPAHINTNKITQAIAVQKDVDGFHYINIGKLAANILEDTFIPCTPAGVMMIIEYQRGRDLSGLDAVIVGRSNIVGKPMAALLIAANATVTIAHSRTRNLAEVCSSADILVVAVGRPHIIKKDWVKQGAIVIDVGINRIEASEKGTNKTRLVGDVDFEEVKEKASAITPVPGGVGPMTIAMLMVNTLKAAAQAHKLPLPKF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP019781
EMBL· GenBank· DDBJ
AQX19272.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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