A0A1S6WSI0 · A0A1S6WSI0_9HYPH
- ProteinBifunctional protein FolD
- GenefolD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids299 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 168-170 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 193 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 234 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Alphaproteobacteria > Hyphomicrobiales > Bartonellaceae > Bartonella
Accessions
- Primary accessionA0A1S6WSI0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 5-120 | Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic | |||
Domain | 123-290 | Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding | |||
Sequence similarities
Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length299
- Mass (Da)32,340
- Last updated2017-05-10 v1
- Checksum1D60358033D6FF2F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP019781 EMBL· GenBank· DDBJ | AQX19272.1 EMBL· GenBank· DDBJ | Genomic DNA |